Results 111 to 120 of about 877,283 (253)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Scalable Autoregressive 3D Molecule Generation
CoRRAdded link to code; corrected results on disabling data augmentation in Appendix Table 4; logit prediction uses Lin, not ...
Austin H. Cheng +2 more
openaire +2 more sources
GA/SA-based hybrid techniques for the scheduling of generator maintenance in power systems [PDF]
, 2000 YesProposes the application of a genetic algorithm (GA) and simulated annealing (SA) based hybrid approach for the scheduling of generator maintenance in power systems using an integer representation.
Galloway, S.J. +8 more
core +1 more source
Sensors, 2019 In this study, 4-mercaptobenzoic acid (MBA)-Au nanorods conjugated with a GPR120 antibody were developed as a highly sensitive surface-enhanced Raman spectroscopy (SERS) probe, and were applied to detect the interaction of fatty acids (FA) and their ...
Han Zhang +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
BCODMO/pipeline-generator: v0.0.2
, 2019 <p>Release after two weeks of work completed on 3/29/19. To be used with the same named release in pipeline-web.</p> <ul> <li>Upgrade to datapackage-pipelines 2.0</li> <li>Add rename_fields processor (<a href="https:
Conrad Schloer, Amber York
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Diathermic Evaluation of Sustained Acoustic Medicine with Cannabidiol Coupling Gel
Applied SciencesMusculoskeletal (MSK) pain is a prevalent clinical condition that significantly impairs quality of life, and current treatment options are not effective on all patients or have severe, long-term side effects.
Ethan Bates +3 more
doaj +1 more source