Results 21 to 30 of about 105,165 (285)

Impact of receiver reaction mechanisms on the performance of molecular communication networks [PDF]

, 2013
In a molecular communication network, transmitters and receivers communicate by using signalling molecules. At the receivers, the signalling molecules react, via a chain of chemical reactions, to produce output molecules.
Chou, Chun Tung
core   +1 more source

Measuring Intracellular H2O2 in Intact Human Cells Using the Genetically Encoded Fluorescent Sensor HyPer7

Bio-Protocol, 2022
Depending on its local concentration, hydrogen peroxide (H2O2) can serve as a cellular signaling molecule but can also cause damage to biomolecules.
Lianne Jacobs, Michaela Hoehne, Jan Riemer   +2 more
doaj   +1 more source

In-situ electro-responsive through-space coupling enabling foldamers as volatile memory elements

Nature Communications, 2023
Voltage-gated processing units are fundamental components for non-von Neumann architectures like memristor and electric synapses, on which nanoscale molecular electronics have possessed great potentials.
Jinshi Li, Pingchuan Shen, Zeyan Zhuang, Junqi Wu, Ben Zhong Tang, Zujin Zhao   +5 more
doaj   +1 more source

Diversity oriented Deep Reinforcement Learning for targeted molecule generation

Journal of Cheminformatics, 2021
In this work, we explore the potential of deep learning to streamline the process of identifying new potential drugs through the computational generation of molecules with interesting biological properties.
Tiago Pereira, Maryam Abbasi, Bernardete Ribeiro, Joel P. Arrais   +3 more
doaj   +1 more source

Score-Based Generative Models for Molecule Generation

, 2022
Recent advances in generative models have made exploring design spaces easier for de novo molecule generation. However, popular generative models like GANs and normalizing flows face challenges such as training instabilities due to adversarial training and architectural constraints, respectively.
Gnaneshwar, Dwaraknath, Ramsundar, Bharath, Gandhi, Dhairya, Kurchin, Rachel, Viswanathan, Venkatasubramanian   +4 more
openaire   +2 more sources

A Light-Up Probe for Detection of Adenosine in Urine Samples by a Combination of an AIE Molecule and an Aptamer

Sensors, 2017
A light-up fluorescent probe for the detection of adenosine was constructed with an AIE (aggregation-induced emission) molecule and a DNA aptamer. The AIE molecule was used as a signal generator, and the DNA aptamer was used as a recognition element for ...
Yingying Hu, Jingjing Liu, Xiangyu You, Can Wang, Zhen Li, Weihong Xie   +5 more
doaj   +1 more source

Dynamic nanoassemblies derived from small-molecule homodimeric prodrugs for in situ drug activation and safe osteosarcoma treatment

iScience, 2023
Summary: Supramolecular prodrug self-assembly is a cost-effective and powerful approach for creating injectable anticancer nanoassemblies. Herein, we describe the self-assembly of small-molecule prodrug nanotherapeutics for tumor-restricted pharmacology ...
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li   +7 more
doaj   +1 more source

Augmented Hill-Climb increases reinforcement learning efficiency for language-based de novo molecule generation

Journal of Cheminformatics, 2022
A plethora of AI-based techniques now exists to conduct de novo molecule generation that can devise molecules conditioned towards a particular endpoint in the context of drug design.
Morgan Thomas, Noel M. O’Boyle, Andreas Bender, Chris de Graaf   +3 more
doaj   +1 more source

Mol-CycleGAN - a generative model for molecular optimization [PDF]

, 2019
Designing a molecule with desired properties is one of the biggest challenges in drug development, as it requires optimization of chemical compound structures with respect to many complex properties.
A Gupta, D Rogers, E Ratti, H Chen, J Bajorath, J Besnard, MH Segler, R Winter, T Sterling, VS Rao   +9 more
core   +2 more sources

Genetic control of a central pattern generator: rhythmic oromotor movement in mice is controlled by a major locus near Atp1a2. [PDF]

PLoS ONE, 2012
Fluid licking in mice is a rhythmic behavior that is controlled by a central pattern generator (CPG) located in a complex of brainstem nuclei. C57BL/6J (B6) and DBA/2J (D2) strains differ significantly in water-restricted licking, with a highly heritable
John D Boughter, Megan K Mulligan, Steven J St John, Kenichi Tokita, Lu Lu, Detlef H Heck, Robert W Williams   +6 more
doaj   +1 more source