Results 31 to 40 of about 30,350 (257)
Genetic control of a central pattern generator: rhythmic oromotor movement in mice is controlled by a major locus near Atp1a2. [PDF]
PLoS ONE, 2012 Fluid licking in mice is a rhythmic behavior that is controlled by a central pattern generator (CPG) located in a complex of brainstem nuclei. C57BL/6J (B6) and DBA/2J (D2) strains differ significantly in water-restricted licking, with a highly heritable
John D Boughter +6 more
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Neural Regeneration Research, 2022 Serotonin is a monoamine neurotransmitter synthetized in various populations of brainstem neurons. In the spinal cord, descending serotonergic projections regulate postural muscle tone, locomotion and rhythm and coordination of movements via the Central ...
Julie Fourneau, Florence M Bareyre
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Powerful molecule generation with simple ConvNet
Bioinformatics, 2022 AbstractMotivationAutomated molecule generation is a crucial step in in-silico drug discovery. Graph-based generation algorithms have seen significant progress over recent years. However, they are often complex to implement, hard to train and can under-perform when generating long-sequence molecules. The development of a simple and powerful alternative
Hongyang K Yu, Hongjiang C Yu
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Nature Communications, 2023 Isopropyl alcohol molecules, as a biomarker for anti-virus diagnosis, play a significant role in the area of environmental safety and healthcare relating volatile organic compounds. However, conventional gas molecule detection exhibits dramatic drawbacks,
Jianxiong Zhu +9 more
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Journal of Cheminformatics, 2021 Many contemporary cheminformatics methods, including computer-aided de novo drug design, hold promise to significantly accelerate and reduce the cost of drug discovery.
M. Sicho +3 more
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A Deep Generative Model for Fragment-Based Molecule Generation
CoRR, 2020 Molecule generation is a challenging open problem in cheminformatics. Currently, deep generative approaches addressing the challenge belong to two broad categories, differing in how molecules are represented. One approach encodes molecular graphs as strings of text, and learns their corresponding character-based language model. Another, more expressive,
Podda, M, Bacciu, D, Micheli, A
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Integrating synthetic accessibility with AI-based generative drug design
Journal of Cheminformatics, 2023 Generative models are frequently used for de novo design in drug discovery projects to propose new molecules. However, the question of whether or not the generated molecules can be synthesized is not systematically taken into account during generation ...
Maud Parrot +7 more
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Rapid determination of apolipoprotein E genotype using a heteroduplex generator
Journal of Lipid Research, 1999 The apoE gene exhibits two common polymorphisms that have been associated with both coronary artery disease and Alzheimer's disease. The polymorphisms create the three allelic isoforms E2, E3, and E4 which are encoded by Cys–Cys, Cys–Arg, and Arg–Arg at ...
M.K. Bolla, N. Wood, S.E. Humphries
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Atoms, 2020 A model for the description of proton collisions from molecules composed of atoms such as hydrogen, carbon, nitrogen, oxygen and phosphorus (H, C, N, O, P) was recently extended to treat collisions with multiply charged ions with a focus on net ...
Hans Jürgen Lüdde +3 more
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Retrieval-based Controllable Molecule Generation
CoRR, 2022 <p>Submitted - <a href="/records/k5v8y-gam02/files/2208.11126.pdf?download=1">2208.11126.pdf</a></p>
Wang, Zichao +5 more
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