Results 51 to 60 of about 104,482 (285)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Triplet-Energy Quenching Functions of Antioxidant Molecules

Antioxidants, 2022
UV-like DNA damage is created in the dark by chemiexcitation, in which UV-activated enzymes generate reactive oxygen and nitrogen species that create a dioxetane on melanin.
Carlos Angelé-Martínez, Leticia Christina Pires Goncalves, Sanjay Premi, Felipe A. Augusto, Meg A. Palmatier, Saroj K. Amar, Douglas E. Brash   +6 more
doaj   +1 more source

Energy Efficiency and Economic Aspects of Mining Wastes Utilization within the Closed Cycle of Underground Gas Generator [PDF]

, 2017
Energy efficiency of coal gasification with possible utilization of mining wastes within ecologically closed gas generator cycle has been considered.
CABANA, Edgar Cáceres, DYCHKOVSKYI, Roman, FALSHTYNSKYI, Volodymyr, PIVNYAK, Gennadiy   +3 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Quantum-assisted fragment-based automated structure generator (QFASG) for small molecule design: an in vitro study

Frontiers in Chemistry
Introduction: The significance of automated drug design using virtual generative models has steadily grown in recent years. While deep learning-driven solutions have received growing attention, only a few modern AI-assisted generative chemistry platforms
Sergei Evteev, Yan Ivanenkov, Ivan Semenov, Maxim Malkov, Olga Mazaleva, Artem Bodunov, Dmitry Bezrukov, Denis Sidorenko, Victor Terentiev, Alex Malyshev, Bogdan Zagribelnyy, Anastasia Korzhenevskaya, Alex Aliper, Alex Zhavoronkov   +13 more
doaj   +1 more source

Emergent L\'evy behavior in single-cell stochastic gene expression

, 2017
Single-cell gene expression is inherently stochastic; its emergent behavior can be defined in terms of the chemical master equation describing the evolution of the mRNA and protein copy numbers as the latter tends to infinity.
Jia, Chen, Qian, Hong, Zhang, Michael Q.
core   +1 more source

Harmonic generation in free molecules [PDF]

Journal of Physics B: Atomic and Molecular Physics, 1980
A molecular theory of harmonic generation in free molecules is developed using the principles of quantum electrodynamics. A Cartesian tensor formalism is employed and emphasis is placed on the rotational average which is required to account for the random molecular orientations in the pump beam.
openaire   +3 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

The Possibility of Destruction of Cellular NADPH in the Presence of Free Fe(II) Ion, Arsine, and Other Hazardous Species [PDF]

Research in Molecular Medicine, 2022
Background: As the nicotinamide adenine dinucleotide phosphate (NADPH) is the key natural electron generator of the alive cells, investigation of the possibility of inactivation or even destruction of it by hazardous chemical molecules or ions seems to ...
Seyyed Amir Siadati, Mohammad Ali Ebrahimzadeh, Esmaeil Babazadeh   +2 more
doaj  

Mechanistic Investigation of Electrostatic Field‐Enhanced Water Evaporation

Advanced Science, 2021
Investigations on external electrostatic field (EEF)‐enhanced liquid water evaporation have been reported decades ago, which suggest that molecular alignment and polarization tuned by EEF accelerating the phase change process could be responsible for EEF‐
Jipeng Fei, Bin Ding, See Wee Koh, Junyu Ge, Xingli Wang, Liquan Lee, Zixu Sun, Mengqi Yao, Yonghao Chen, Huajian Gao, Hong Li   +10 more
doaj   +1 more source