Results 61 to 70 of about 104,482 (285)
Dynamic disorder in simple enzymatic reactions induces stochastic amplification of substrate [PDF]
, 2017 A growing amount of evidence points to the fact that many enzymes exhibit fluctuations in their catalytic activity, which are associated with conformational changes on a broad range of timescales. The experimental study of this phenomenon, termed dynamic
Gupta, Ankit +2 more
core +2 more sources
Generalized Stern-Gerlach Effect for Chiral Molecules [PDF]
Physical Review Letters, 2007 The Stern-Gerlach effect is well-known as spin-dependent splitting of a beam of atoms with magnetic moments by a magnetic-field gradient. Here, we show that an induced gauge potential may lead to a similar effect for chiral molecules. In the presence of three inhomogeneous light fields, the center-of-mass of a three-level chiral molecule is subject to ...
Li, Yong, Bruder, C., Sun, C. P.
openaire +4 more sources
Generating Flavor Molecules Using Scientific Machine Learning
ACS Omega, 2023 النكهة هي عنصر أساسي في تطوير العديد من المنتجات في السوق. أدى الاستهلاك المتزايد للوجبات المصنعة والسريعة والأغذية المعبأة الصحية إلى زيادة الاستثمار في عوامل النكهة الجديدة وبالتالي في الجزيئات ذات خصائص النكهة. في هذا السياق، يطرح هذا العمل نهجًا علميًا للتعلم الآلي (SciML) لتلبية هذه الحاجة إلى هندسة المنتج.
Luana P. Queiroz +7 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel +3 more
wiley +1 more source
Coal as an energy source and its impacts on human health
Energy Geoscience, 2021 Attempts to secure more energy, food, and infrastructure leave a trail of environmental contamination and human health hazards. Coal is a fossil fuel and nonrenewable energy source that is combusted and used to generate electricity.
Juciano Gasparotto +1 more
doaj +1 more source
Origins of concentration dependence of waiting times for single-molecule fluorescence binding
, 2012 Binary fluorescence time series obtained from single-molecule imaging experiments can be used to infer protein binding kinetics, in particular, association and dissociation rate constants from waiting time statistics of fluorescence intensity changes. In
Pearson, John E., Yang, Jin
core +1 more source
Optimal control of multiscale systems using reduced-order models [PDF]
, 2014 We study optimal control of diffusions with slow and fast variables and address a question raised by practitioners: is it possible to first eliminate the fast variables before solving the optimal control problem and then use the optimal control computed ...
Hartmann, Carsten +3 more
core +5 more sources
Learned Feature Generation for Molecules [PDF]
, 2018 When classifying molecules for virtual screening, the molecular structure first needs to be converted into meaningful features, before a classifier can be trained. The most common methods use a static algorithm that has been created based on domain knowledge to perform this generation of features. We propose an approach where this conversion is learned
Winter, Patrick +2 more
openaire +2 more sources
, 2011 In this work we monitor the catalytic mechanism of P-glycoprotein (Pgp) using single-molecule fluorescence resonance energy transfer (FRET). Pgp, a member of the ATP binding cassette family of transport proteins, is found in the plasma membrane of animal
Boersch, Michael +4 more
core +1 more source
Retrieval-based Controllable Molecule Generation
, 2022 Generating new molecules with specified chemical and biological properties via generative models has emerged as a promising direction for drug discovery. However, existing methods require extensive training/fine-tuning with a large dataset, often unavailable in real-world generation tasks.
Wang, Zichao +5 more
openaire +2 more sources