Results 71 to 80 of about 30,351 (277)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Absolute optical frequency measurements of iodine-stabilized He-Ne laser at 633 nm by using a femtosecond laser frequency comb [PDF]
International Journal of Metrology and Quality Engineering, 2012 The optical frequency comb generator (OFCG) is an attractive optical reference source for various applications such as optical frequency metrology, precision spectroscopy and telecommunications [D.J. Jones, S.A. Diddams, J.K. Ranka, A.
Samoudi B. +3 more
doaj +1 more source
Generative Network Complex for the Automated Generation of Drug-like Molecules
Journal of Chemical Information and Modeling, 2020 Current drug discovery is expensive and time-consuming. It remains a challenging task to create a wide variety of novel compounds with desirable pharmacological properties and cheaply available to low-income people. In this work, we develop a generative network complex (GNC) to generate new drug-like molecules based on the multi-property optimization ...
Kaifu Gao +3 more
openaire +4 more sources
Evaluation of Performance and Bias of a Goal Directed Syntehsis Aware De Novo Molecule Generator
, 2022 Searching the chemical space for practically obtainable molecules with desired biological interactions is a challenging task which promises great rewards. Among the most difficult challenges of the field are synthesizability and evaluation.
Ielanskyi, Mykyta
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways
Antioxidants, 2019 The heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron.
J. Catharina Duvigneau +2 more
doaj +1 more source
, 2021 To unravel the structures of C12H12O7 isomers, identified as light-absorbing photooxidation products of syringol in atmospheric chamber experiments, we apply a graph-based molecule generator and machine learning workflow.
Contin, Mario +9 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Journal of Nanobiotechnology, 2022 Background Methicillin-resistant Staphylococcus aureus (MRSA) biofilm-associated bacterial infection is the primary cause of nosocomial infection and has long been an ongoing threat to public health.
Yue Zhang +8 more
doaj +1 more source
MOESM1 of QBMG: quasi-biogenic molecule generator with deep recurrent neural network
, 2019 Additional file 1.
Xin Yan (17064) +6 more
core +1 more source