Results 181 to 190 of about 3,169,273 (304)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Structural modification of functionalized carbazoles: from Z' = 1 to Z' = 6. [PDF]

Acta Crystallogr B Struct Sci Cryst Eng Mater
Abualnaja M, Probert MR, Hall MJ, Brock CP, Waddell PG.   +4 more
europepmc   +1 more source

The Virtual Museum of Minerals and Molecules

, 2005
The 3-D visualizations of molecules and minerals at this site utilize a plug-in viewer, which allows them to be interactively zoomed and rotated so they can be viewed from all angles, much as with a real molecule.

core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

NMR of paramagnetic molecules : applications to metallobiomolecules and models /

NMR of Paramagnetic Molecules: Applications to Metallobiomolecules and Models, Second Edition is a self-contained, comprehensive reference for chemists, physicists, and life scientists whose research involves analyzing paramagnetic compounds.
Bertini, Ivano,author., Luchinat, C.(Claudio),author., Parigi, Giacomo,author., Ravera, Enrico,author.   +3 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Correction: Arockiaraj et al. Topological and Spectral Properties of Wavy Zigzag Nanoribbons. <i>Molecules</i> 2023, <i>28</i>, 152. [PDF]

Molecules
Arockiaraj M, Fiona JC, Kavitha SRJ, Shalini AJ, Balasubramanian K.   +4 more
europepmc   +1 more source

THE ARCHITECTURE OF MOLECULES [PDF]

Proceedings of the National Academy of Sciences, 1964
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Selectivity Implications of Docking Libraries with Greater and Lesser Similarities to Bio-like Molecules. [PDF]

J Med Chem
Hall BW, Sakamoto K, Huang XP, Irwin JJ, Shoichet BK, Roth BL.   +5 more
europepmc   +1 more source