Results 51 to 60 of about 116,948 (101)

Molybdenum cofactors, enzymes and pathways

Nature, 2009
The trace element molybdenum is essential for nearly all organisms and forms the catalytic centre of a large variety of enzymes such as nitrogenase, nitrate reductases, sulphite oxidase and xanthine oxidoreductases. Nature has developed two scaffolds holding molybdenum in place, the iron-molybdenum cofactor and pterin-based molybdenum cofactors ...
Guenter Schwarz, Markus Ribbe, Ralf R Mendel   +2 more
exaly   +3 more sources

Molybdenum Cofactor Biosynthesis

, 2016
The biosynthesis of the molybdenum cofactor (Moco) is highly conserved among all kingdoms of life. In all molybdoenzymes with the exception of nitrogenase, the molybdenum atom is coordinated to a dithiolene group present in the pterin-based 6-alkyl side chain of molybdopterin (MPT).
Leimkühler, Silke (Prof. Dr.), Mendel, Ralf-Rainer (Prof. Dr.)   +1 more
openaire   +3 more sources

Regulation of molybdenum cofactor of maize leaf

Phytochemistry, 1987
Molybdenum cofactor and nitrate reductase were extracted from maize leaf and assayed using established methods. While both applied nitrate and light increased nitrate reductase activity, only nitrate was required to increase molybdenum cofactor to its ...
Wilbur H. Campbell
exaly   +2 more sources

Pterin chemistry and its relationship to the molybdenum cofactor [PDF]

Coordination Chemistry Reviews, 2011
The molybdenum cofactor is composed of a molybdenum coordinated by one or two rather complicated ligands known as either molybdopterin or pyranopterin. Pterin is one of a large family of bicyclic N-heterocycles called pteridines.
Partha Basu, Sharon J N Burgmayer
exaly   +2 more sources

The history of the discovery of the molybdenum cofactor and novel aspects of its biosynthesis in bacteria

Coordination Chemistry Reviews, 2011
The biosynthesis of the molybdenum cofactor in bacteria is described with a detailed analysis of each individual reaction leading to the formation of stable intermediates during the synthesis of molybdopterin from GTP.
Silke Leimkühler, K V Rajagopalan, Margot M Wuebbens   +2 more
exaly   +2 more sources

A Turkish Case with Molybdenum Cofactor Deficiency

Nucleosides, Nucleotides and Nucleic Acids, 2006
Molybdenum cofactor deficiency (MIM 252150) is a rare progressive neurodegenerative disorder with about 100 cases reported worldwide. We have identified a male with molybdenum cofactor deficiency and analyzed the molybdenum cofactor synthesis (MOCS) 1 ...
Ali Dursun, H Serap Kalkanoğlu, M Hosoyamada   +2 more
exaly   +2 more sources

Molybdenum cofactor deficiency

The Journal of Pediatrics, 1993
We describe a new case of molybdenum cofactor deficiency, an underrecognized inborn error of metabolism that results in neonatal seizures and neurologic abnormalities. Characteristic biochemical defects in affected individuals include hypouricemia, elevated urine sulfate (detectable by dipstick), and elevated S-sulfocysteine (detectable by anion ...
G L, Arnold, C L, Greene, J P, Stout, S I, Goodman   +3 more
openaire   +2 more sources

Molybdenum cofactor deficiency

Molecular Genetics and Metabolism, 2016
Molybdenum cofactor deficiency (MoCD) is a severe autosomal recessive inborn error of metabolism first described in 1978. It is characterized by a neonatal presentation of intractable seizures, feeding difficulties, severe developmental delay, microcephaly with brain atrophy and coarse facial features.
Paldeep S, Atwal, Fernando, Scaglia
openaire   +2 more sources

Identification of a Bis-molybdopterin Intermediate in Molybdenum Cofactor Biosynthesis in Escherichia coli*

Journal of Biological Chemistry, 2013
The molybdenum cofactor is an important cofactor, and its biosynthesis is essential for many organisms, including humans. Its basic form comprises a single molybdopterin (MPT) unit, which binds a molybdenum ion bearing three oxygen ligands via a ...
Michael Haumann, Kajsa G V Sigfridsson
exaly   +2 more sources

The biosynthesis of the molybdenum cofactors

JBIC Journal of Biological Inorganic Chemistry, 2014
The biosynthesis of the molybdenum cofactors (Moco) is an ancient, ubiquitous, and highly conserved pathway leading to the biochemical activation of molybdenum. Moco is the essential component of a group of redox enzymes, which are diverse in terms of their phylogenetic distribution and their architectures, both at the overall level and in their ...
Ralf R, Mendel, Silke, Leimkühler
openaire   +2 more sources