Results 231 to 240 of about 138,328 (297)

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso   +3 more
wiley   +1 more source

Mitochondria‐Directed Redox Phospholipid Polymers for Cancer Therapy

open access: yesCancer Science, EarlyView.
A mitochondria‐directed redox polymer containing an antioxidant‐oxidizing ferrocene unit and a triphenylphosphonium unit is prepared by a simple copolymerization strategy for cancer treatment. Incorporation of an appropriate amount of the directed unit enhances anticancer activity, elevates intracellular ROS levels, induces apoptosis, and suppresses in 
Yuma Kato   +3 more
wiley   +1 more source

A clean van der Waals interface between the high-<i>k</i> dielectric zirconium oxide and two-dimensional molybdenum disulfide. [PDF]

open access: yesNat Electron
Yan H   +10 more
europepmc   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

open access: yesThe FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe   +5 more
wiley   +1 more source

Molybdenum Disulfide and Reduced Graphene Oxide Hybrids as Anodes for Low-Temperature Lithium- and Sodium-Ion Batteries. [PDF]

open access: yesNanomaterials (Basel)
Vorfolomeeva AA   +6 more
europepmc   +1 more source

Exfoliated Molybdenum Disulfide Nanosheet Networks as Sensing Materials for Nitrogen Dioxide Detection. [PDF]

open access: yesACS Appl Nano Mater
Urs K   +9 more
europepmc   +1 more source

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