Results 61 to 70 of about 5,582 (291)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molybdenum distributions and variability in drinking water from England and Wales [PDF]

, 2014
An investigation has been carried out of molybdenum in drinking water from a selection of public supply sources and domestic taps across England and Wales.
Cooper, D.M., Lapworth, D.J., Smedley, P.L.   +2 more
core   +1 more source

Possible Methods Recovery of Metals from Flotation Tailings Copper-Molybdenum Ores

Journal of Siberian Federal University. Engineering & Technologies, 2016
800x600 In order to reduce losses of metal with tails cycle of collective flotation of copper-molybdenum ore deposits was performed a preliminary assessment of the effectiveness of enrichment tailings using gravity and flotation methods. The results showed the prospect of using both methods, but in the case of gravity separation is possible ...
Natalia K. Algebraistova, Anna S. Markova, Ivan V. Prokopiev, Denis M. Kolotushkin   +3 more
openaire   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Research on Application Technology of Molybdenum Tailings Sand Concrete

IOP Conference Series: Materials Science and Engineering, 2019
Abstract Molybdenum tailings sand is used as a fine aggregate to replace part of the construction sand, which can effectively solve the environmental pollution problems caused by the molybdenum tailings pond and has high utilization value.
openaire   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Life Cycle Environmental Evaluation Framework for Mining Waste Concrete: Insights from Molybdenum Tailings Concrete in China

Buildings
This study uses the case of substituting natural river sand with molybdenum tailings in concrete production in China to propose a methodological framework for evaluating the life cycle environmental impact of concrete materials.
Shan Gao, Jicheng Xu, Zhenhua Huang, Tomoya Nishiwaki, Chuanxin Rong   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Life Cycle Inventories of Metals and Methodological Aspects of Inventorying Material Resources in ecoinvent (7 pp) [PDF]

, 2018
Goal, Scope and Background: The ecoinvent database provides harmonised generic life cycle inventories for metal production and processing. They can be used as background data for different LCA applications.
Althaus, Hans-Jörg, Classen, Mischa
core