Results 41 to 50 of about 107,221 (240)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

An integrated approach to AMD mitigation through sulfide removal from tailings [PDF]

, 2010
Includes bibliographical references (leaves 67-73).The formation of acid mine drainage (AMD) from the microbial oxidation of sulfides in mineral waste deposits is one of the major challenges facing the mining industry worldwide.
Hesketh, Alexander H
core   +1 more source

Water flow through tailings dams [PDF]

, 1993
Water levels in tailings dams are generally lower than those of standard earth dams. Previously, other authors have shown that embankment geometry and variation in permeability can be responsible for a concave upwards steady state seepage line.
Welch, Jonathan Paul
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Research on the Process of Preparing High-quality Silicon Calcium Potassium Magnesium Fertilizer from Molybdenum Tailings

Kuangchan zonghe liyong
[Objective] To achieve the enrichment of nutrients in tailings and further reduce heavy metal elements, and to realize the large-scale utilization of tailings. Taking a certain molybdenum tailings in Hebei Province as the object, the process research for
Quanping TU, Hongfei WEI, Tuanliu HU, Yifan LI, Kun LIU, Qing SHI   +5 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Mechanical Properties of 3D-Printed Molybdenum Tailings Mortar

Applied Sciences
As an innovative approach to advancing sustainable construction, this study explores the integration of molybdenum tailings as fine aggregate in 3D-printed mortar.
Shan Gao, Tianyu Li, Jian Yuan, Tomoya Nishiwaki, Zhenhua Huang   +4 more
doaj   +1 more source

Heavy metal immobilisation and particle cementation of tailings by biomineralisation

, 2018
Tailings are the wastes remaining after mineral beneficiation. Leaching of heavy metals in tailings can pollute the environment and poor mechanical properties of tailings can lead to the collapse of tailings dams or reduced capacity of tailings ponds ...
Xiaohui Cheng, Xihai Chen, Hongxian Guo
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source