Results 21 to 30 of about 33,740 (295)

Rotation curve of the Milky Way

, 2012
We use SEGUE and Hipparcos data to restrict the behaviour of the rotation curve of the Milky Way in the solar neighbourhood. Then we construct a density model of the Milky Way which best reproduces the available observations of the rotation curve and is ...
Lee Y.S., Beers T.C., Golubov O., Just A.   +3 more
core   +2 more sources

Study on the Seismic Performance of Through-tenon Joints with Pullout Tenon Gaps between Mortise and Tenon Shoulder

BioResources, 2023
Through-tenon joints are widely used in ancient timber buildings. To study the influence of the gaps between mortise and tenon shoulder on the seismic performance of through-tenon joints, a 1:3.52 scaled model was constructed and used for low cyclic ...
Junhong Huan, Zemeng Sun, Xiaodong Guo, Tianyang Chu, Xiaoyi Zhou, Wei Wang, Yating Yang   +6 more
doaj   +2 more sources

Influence of Joint Flexibility on Vibration Analysis of Free-Free Beams

Nonlinear Engineering, 2014
In present work, joint flexibility (or looseness) of the free-free beam is investigated by using a two noded beam finite element formulation with transverse displacement and joint rotations as the degrees of freedom per node at joint location ...
Gunda Jagadish Babu, Krishna Y.
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Finite Element Modeling of Cold-Formed Steel Bolted Moment Connection

Journal of Civil Engineering
This paper describes the finite element procedure for modeling cold-formed steel bolted moment connection to simulate hysteretic moment-rotation behavior and failure mode. The connection element consists of CFS curved flange beams, double-lipped channel
Muhamad Fauzan Akbari, Data Iranata, Djoko Irawan   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluation of gusset plate moment connection at elevated temperatures using gene expression programming and finite element model

Results in Engineering
In this study, the performance of the gusset plate moment connection under fire conditions is examined using finite element modeling and genetic algorithm. Following validation, the finite element modeling is conducted in three stages.
Hesam Ketabdari, Amir Saedi Daryan
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source