Results 61 to 70 of about 247,963 (294)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Modified Three-Parameter Power Model to Predict Moment-Rotation Curve of Top- and Seat-Angle Connection [PDF]

open access: yesAmerican Journal of Civil Engineering, 2017
This study conducted on improving three-parameter power model [1] to estimate ultimate moment of connections based on the failure mechanisms developed by more practical means and finally, to predict moment-rotation relations of top- and seat-angle connections for intrinsic replacement of experimental curves and/or finite element (FE) analysis results ...
openaire   +1 more source

A Self-Consistent Dynamical Model for the COBE Detected Galactic Bar [PDF]

open access: yes, 1995
A 3D steady state stellar dynamical model for the Galactic bar is constructed with 485 orbit building blocks using an extension of Schwarzschild technique. The weights of the orbits are assigned using non-negative least square method.
Zhao, HongSheng
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Influence of Non-Uniform Rail Loads on the Rotation of Railway Sleepers

open access: yesApplied Sciences
This article presents an innovative, two-stage railway track model, which takes into consideration the rotation of railway sleepers due to non-uniform loads on rails. Examples of determining the dynamic response of the railway track are provided.
Włodzimierz Czyczuła   +1 more
doaj   +1 more source

On general relativistic uniformly rotating white dwarfs

open access: yes, 2012
The properties of uniformly rotating white dwarfs (RWDs) are analyzed within the framework of general relativity. Hartle's formalism is applied to construct the internal and external solutions to the Einstein equations.
Barstow   +16 more
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Kapasitas Momen Maksimum Pondasi Tiang Pendek Silindris Akibat Beban Lateral pada Tanah Lempung dengan Metode Kurva P-Y

open access: yesMedia Komunikasi Teknik Sipil, 2015
For a certain structure, lateral loads are more dominant than vertical loads. A foundation with a lateral load is due to overturning force relying on good contact between the pile and the soil.
Utari Wessy Andriani, Ita Suhartatik
doaj   +1 more source

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