Results 121 to 130 of about 1,518,720 (358)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Bondad de ajuste empleando la función generadora demomentos Goodness-of-Fit Employing the Moment Generating Function

open access: yesRevista Colombiana de Estadística, 2010
Proponemos una estadística para evaluar la bondad de ajuste, donde se emplearon las funciones generatrices de momentos muestral y poblacional; a partir de la información considerada se encontró que la estadística Gn tuvo un comportamiento diferente de ...
LUIS ALFONSO MUÑOZ   +1 more
doaj  

Generalized Moment Generating Functions of Random Variables and Their Probability Density Functions

open access: yes, 2017
This paper seeks to develop a generalized method of generating the moments of random variables and their probability distributions. The Generalized Moment Generating Function is developed from the existing theory of moment generating function as the ...
Matthew Chukwuma Michael   +3 more
semanticscholar   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

New lifetime Shanker Weibull distribution: Structure and Properties

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences
This paper introduces a new model with two parameters titled “Shanker Weibull distribution". This distribution is obtained by merging the Shanker distribution with a scale of one parameter and the Weibull distribution with a shape parameter.
Maysaa Jalil Mohammed   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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