Results 51 to 60 of about 709,578 (283)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Right Truncated Shankar Distribution and its Properties

Ibn Al-Haitham Journal for Pure and Applied Sciences
       Since the importance of truncated distributions has increased in many scientific fields in recent years and they provide valuable insights when dealing with censored or truncated data, this paper presents the Right Truncated Shanker Distribution ...
Bayda Atiya Kalaf , Sairan Hamza Raheem, Feras Sh. M. Batah   +2 more
doaj   +1 more source

Matrix Ansatz, lattice paths and rook placements [PDF]

Discrete Mathematics & Theoretical Computer Science, 2009
We give two combinatorial interpretations of the Matrix Ansatz of the PASEP in terms of lattice paths and rook placements. This gives two (mostly) combinatorial proofs of a new enumeration formula for the partition function of the PASEP.
S. Corteel, M. Josuat-Vergès, T. Prellberg, M. Rubey   +3 more
doaj   +1 more source

On Estimating the Cumulant Generating Function of Linear Processes [PDF]

, 2018
We compare two estimates of the cumulant generating function of a stationary linear process. The first estimate is based on the empirical moment generating function.
Beran, Jan, Ghosh, Sucharita
core  

Appell polynomials and their relatives II. Boolean theory

, 2007
The Appell-type polynomial family corresponding to the simplest non-commutative derivative operator turns out to be connected with the Boolean probability theory, the simplest of the three universal non-commutative probability theories (the other two ...
Anshelevich, Michael
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A flexible generalized XLindley distribution with application to engineering

Scientific African
This paper presents a novel three-parameter distribution called the exponentiated generalized XLindley distribution. The distribution’s probability density function can be positively or negatively skewed, reverse-J or symmetric.
Regent Retrospect Musekwa, Boikanyo Makubate   +1 more
doaj   +1 more source

The structural properties of the Gompertz-two-parameter-Lindley distribution and associated inference

Open Mathematics, 2022
In this article, we propose a Gompertz-two-parameter-Lindley distribution by mixing the frailty parameter of the Gompertz distribution with a two-parameter Lindley distribution. The structural properties of the model, such as shape properties, cumulative
Ou Xionghui, Lu Hezhi, Kong Jingsen
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source