Results 61 to 70 of about 60,178 (261)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A flexible generalized XLindley distribution with application to engineering
Scientific AfricanThis paper presents a novel three-parameter distribution called the exponentiated generalized XLindley distribution. The distribution’s probability density function can be positively or negatively skewed, reverse-J or symmetric.
Regent Retrospect Musekwa +1 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Matrix Ansatz, lattice paths and rook placements [PDF]
Discrete Mathematics & Theoretical Computer Science, 2009 We give two combinatorial interpretations of the Matrix Ansatz of the PASEP in terms of lattice paths and rook placements. This gives two (mostly) combinatorial proofs of a new enumeration formula for the partition function of the PASEP.
S. Corteel +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Performance Analysis of HARQ for Moment Generating Function in Nakagami-m Fading Channels
工程科学与技术, 2014 :A joint optimization algorithm which combines M-QAM with HARQ protocol is proposed for the multi-branch two-top cooperation diversity system to minimize the symbol error rate (SER) and maximize the throughput. Using moment generating function (MGF), the
陈昌川, 饶毓, 赵超莹
doaj
Mathematical Modelling and Analysis, 2015 The Muth distribution is a continuous random variable introduced in the context of reliability theory. In this paper, some mathematical properties of the model are derived, including analytical expressions for the moment generating function, moments ...
Pedro Jodra +2 more
doaj +1 more source