Results 81 to 90 of about 60,178 (261)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
On the Convergence of Sequences of Moment Generating Functions
The Annals of Mathematical Statistics, 1947 The purpose of this paper is to give a few theorems concerning the reciprocal relation between the convergence of a sequence of distribution functions and the convergence of the corresponding sequence of their moment generating functions. The paper consists of two parts. In the first part the univariate case is discussed.
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Tikrit Journal of Administrative and Economic SciencesOver the past years, many academics in mathematical statistics have introduced new continuous distributions to respond to real-world data growth, and this adaptability or flexibility has become essential to this development.
Dalya Dh. Ahmed, Mundher A. Khaleel
doaj +1 more source
Generalized moments of additive functions
Journal of Number Theory, 1984 AbstractElliott's generalization of the Turán-Kubilius inequality is further generalized by establishing an upper bound for the sum Σn≤xF(∣f(n) − A∣), where f is a complex-valued additive arithmetical function, A an arbitrary number and F an arbitrary nonnegative-valued increasing function.
openaire +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Exp-Kumaraswamy Distributions: Some Properties and Applications [PDF]
Journal of Sciences, Islamic Republic of Iran, 2015 In this paper, we propose and study exp-kumaraswamy distribution. Some of its properties are derived, including the density function, hazard rate function, quantile function, moments, skewness and kurtosis.
Z. Javanshiri +2 more
doaj
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source