Results 81 to 90 of about 263,795 (327)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Analysis of air bearing torsion pendulum moment of inertia measurements including nonlinear oscillation and damping [PDF]

, 2023
Jun Wang, Liu Zheng, Yixu Wang, Na Miao, Xiaolin Zhang   +4 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Estimation of characteristics of supported object on vibration isolator using air suspensions

Nihon Kikai Gakkai ronbunshu
An air suspension is one of the fundamental components of a vibration isolator that utilizes a stiffness caused by compressibility of air and damping effect caused by viscosity of air.
Kenta NAKANO, Hiroshi YAMAMOTO, Terumasa NARUKAWA   +2 more
doaj   +1 more source

Moment of inertia–mass universal relations for neutron stars in scalar-tensor theory with self-interacting massive scalar field

European Physical Journal C: Particles and Fields, 2019
We are investigating universal relations between different normalisations of the moment of inertia and the compactness of neutron stars in slow rotation approximation. We study the relations in particular class of massive scalar-sensor theories with self-
Dimitar Popchev, Kalin V. Staykov, Daniela D. Doneva, Stoytcho S. Yazadjiev   +3 more
doaj   +1 more source

Developing Physics Teaching Aids on Moment of Inertia Material using Arduino Nano and TCRT5000 Sensor [PDF]

, 2023
David Nugroho David, Dedy Hamdani, Iwan Setiawan   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Problems of rotational mass in passenger vehicles [PDF]

Transport Problems, 2010
This study presents an overview of methods for calculation of inertia mass in vehicles which impact on inertial resistance. Different opinions in references on rotational mass (engine with clutch mechanism and the road wheels) provided the author an ...
Aleksander UBYSZ
doaj  

Effects of racket moment of inertia on racket head speed, impact location and shuttlecock speed during the badminton smash. [PDF]

Sci Rep, 2023
Towler H, Mitchell SR, King MA.
europepmc   +1 more source

Centroid and moments of an area using a digitizer [PDF]

The centroid and moments of an area program provides the centroid, moments of inertia, product of inertia, radii of gyration, and area of any closed planar geometric figure.
Patch, R. W.
core   +1 more source