Results 31 to 40 of about 17,523 (186)

CYTOTOXICITY, BIOCHEMICAL EFFECT AND ENVIRONMENTAL IMPACT OF MONENSIN ON DAIRY CATTLE [PDF]

Assiut Veterinary Medical Journal, 2015
Rumensin (monensin) is the first ionophore to be approved by the Food and Drug Administration (FDA) for increased milk production efficiency. Monensin treatment at dose of 10 gm /ton in total mixed ration lead to increase both milk production and body ...
ELALFY MAHMOUD, ABDALLAH AHMED ABDNASER, SLEEM RADWAN FATHY   +2 more
doaj   +1 more source

Selection for Resistance to Monensin, Nicarbazin, and the Monensin Plus Nicarbazin Combination

Poultry Science, 1990
Two series of experiments were conducted to assess the relative ability of strains of Eimeria acervulina and Eimeria tenella to develop resistance to monensin (MON), nicarbazin (NIC), and the monensin plus nicarbazin combination (MON plus NIC). The studies were designed so that drug concentrations in the selection experiments were increased whenever ...
K W, Bafundo, T K, Jeffers
openaire   +2 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Effects of Bacillus licheniformis fermentation extract fed alone or with monensin on production performance and feed efficiency of dairy cows

Journal of Dairy Science
: The study objective was to investigate the impact of monensin and a fermentation extract derived from Bacillus licheniformis–derived fermentation extracts (BLFE) when fed alone or in combination on production performance and feed efficiency in ...
S.L. Rigert, P. Hartoonian, S.E. Omale, S. Rodriguez-Jimenez, C.M.K. Bradley, E.A. Horst, S.K. Kvidera, A.W. Holloway, L.H. Baumgard, J.A.D.R.N. Appuhamy   +9 more
doaj   +1 more source

Evaluation of yeast-based additives, as an alternative to ionophores, on rumen fermentation of ruminant diets using an in vitro gas production system

Frontiers in Animal Science, 2023
IntroductionThe study aimed to assess yeast-based additives' effects, as monensin alternatives, on rumen fermentation parameters, greenhouse gas emissions, and ruminal kinetics of ruminant diets using an in vitro system. Three experiments were conducted,
Amanda Regina Cagliari, Elaine Magnani, Fernanda Rigon, Kalista Eloisa Loregian, Kalista Eloisa Loregian, Ana Claudia Casagrande, Bruna Roberta Amâncio, Juliana Bueno da Silva, Veronica Lisboa Santos, Marcos Inácio Marcondes, Eduardo Marostegan Paula, Pedro Del Bianco Benedeti, Renata Helena Branco   +12 more
doaj   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Altered protozoan and bacterial communities and survival of Escherichia coli O157:H7 in monensin-treated wastewater from a dairy lagoon.

PLoS ONE, 2013
Surviving predation is a fitness trait of Escherichia coli O157:H7 (EcO157) that provides ample time for the pathogen to be transported from reservoirs (e.g. dairies and feedlots) to farm produce grown in proximity.
Subbarao V Ravva, Chester Z Sarreal, Robert E Mandrell   +2 more
doaj   +1 more source

Low doses of monensin for lambs fed diets containing high level of ground flint corn

Scientia Agricola, 2020
Two experiments were proposed to evaluate the addition of monensin for lambs fed diets containing a high level of mature ground flint corn. The experimental diets were as follows: no inclusion of monensin (M0) and inclusion of 8 (M8), 16 (M16) and 24 mg ...
Daniel Montanher Polizel, André Storti Martins, Alexandre Arantes Miszura, Marcos Vinícius de Castro Ferraz Júnior, Analisa Vasques Bertoloni, Gabriela Bagio Oliveira, José Paulo Roman Barroso, Evandro Maia Ferreira, Alexandre Vaz Pires   +8 more
doaj   +1 more source