Results 61 to 70 of about 99,269 (234)

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

open access: yesAdvanced Science, Volume 12, Issue 29, August 7, 2025.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao   +12 more
wiley   +1 more source

Operant conditioning in the Mongolian gerbil [PDF]

open access: yesPsychonomic Science, 1969
Mongolian gerbils learned to press a response button to obtain food reward. Responding under three reinforcement schedules was then observed: first, reinforcement occurred after every response; responding was then reinforced on a 15-sec variable-interval schedule; finally, responding was reinforced on a 1-min variable interval.
Nancy Campbell   +2 more
openaire   +1 more source

Neuronal Nuclei That Are Activated After an Offensive Encounter in Female Djungarian Hamster (Phodopus campbelli)

open access: yesAggressive Behavior, Volume 51, Issue 4, July 2025.
ABSTRACT Neural bases of aggression have been analysed mainly in rodent males, finding that the medial preoptic area (mPOA), bed nucleus of the stria terminalis (BNST) ventromedial hypothalamus (VMH), anterior hypothalamus (AHN), and medial amygdala (MeA) integrate the core aggression circuit.
Héctor Reyes‐Arenas   +6 more
wiley   +1 more source

Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging

open access: yesBehavioral and Brain Functions, 2007
Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging.
Teuchert-Noodt Gertraud   +1 more
doaj   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

open access: yesAdvanced Therapeutics, Volume 8, Issue 7, July 2025.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han   +9 more
wiley   +1 more source

Development and validation of an Onchocerca ochengi adult male worm gerbil model for macrofilaricidal drug screening.

open access: yesPLoS Neglected Tropical Diseases, 2019
BackgroundOnchocerciasis currently afflicts an estimated 15 million people and is the second leading infectious cause of blindness world-wide. The development of a macrofilaricide to cure the disease has been hindered by the lack of appropriate small ...
Fidelis Cho-Ngwa   +8 more
doaj   +1 more source

Development and validation of small animal models for onchocerciasis and loiasis microfilaricide discovery.

open access: yesPLoS Neglected Tropical Diseases, 2023
BackgroundOnchocerciasis (river blindness) caused by the filarial worm Onchocerca volvulus is a neglected tropical disease that affects the skin and eyes of humans.
Rene Bilingwe Ayiseh   +6 more
doaj   +1 more source

Nutritional Influences on Brown and Beige Adipocyte: Unraveling the Molecular Mechanisms and Metabolic Implications

open access: yesFood Science &Nutrition, Volume 13, Issue 7, July 2025.
Nutrient‐focused dietary strategies can enhance BAT function and activity, thereby contributing to the modulation of metabolic disorders and the optimization of metabolic health. ABSTRACT Brown adipose tissue (BAT) and beige adipose tissue (beige fat) function as thermogenic organs, significantly influencing human metabolism through various mechanisms.
Yuqun Wang   +5 more
wiley   +1 more source

Micro‐CT Analysis of Rodent Temporal Bones: Identifying Optimal Species for Otological Research

open access: yesLaryngoscope Investigative Otolaryngology, Volume 10, Issue 3, June 2025.
ABSTRACT Objectives Rodents are used in most otological research studies and the choice of the most appropriate animal model may be crucial in studies of ear diseases and in the development of effective treatments. Here, we used micro‐CT to compare temporal bone anatomy between four rodent model animals (guinea pigs, gerbils, rats, and mice) and humans,
Hannah Daoudi   +8 more
wiley   +1 more source

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