Results 51 to 60 of about 5,676,173 (325)

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of prostate carcinoma. [PDF]

, 2016
Prostate cancer is the most commonly diagnosed malignancy and second leading cause of cancer death among men in the United States. In recent years, several new agents, including cancer immunotherapies, have been approved or are currently being ...
Bander, Neil H, Beer, Tomasz M, Drake, Charles G, Fong, Lawrence, Gulley, James L, Harrelson, Stacey, Kantoff, Philip W, Madan, Ravi A, McNeel, Douglas G, Oh, William K, Peace, David J, Petrylak, Daniel P, Porterfield, Hank, Sartor, Oliver, Shore, Neal D, Slovin, Susan F, Stein, Mark N, Vieweg, Johannes   +17 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Clinical validation study of the SignCare Vital Signs Monitor of Fundación Cardiovascular de Colombia

Revista de la Facultad de Medicina, 2016
Introduction: In Colombia, due to the difficult access to health services and to geographic conditions, the implementation and innovation of telemedicine technological tools is a priority.
Leonardo Andrés Rodríguez-Salazar, Edna Magaly Gamboa-Delgado, Sherneyko Plata Rangel, Oscar Alberto Mantilla-Prada, Eugenio Sarmiento-Caraballo, José Domingo Rincón-Riveros   +5 more
doaj   +1 more source

Medication Complications in Extracorporeal Membrane Oxygenation. [PDF]

, 2017
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics.
Aebi, Ami G. Shah, Anderson, Arlt, Barr, Barthelemy, Beiderlinden, Bein, Bembea, Bhatt-Meht, Boucher, Brandi N. Thoma, Brown, Buck, Buscher, Chung, Dagan, Dagan, de Montmollin, De Rosa, DeGrado, Donadello, Donadello, Dzierba, Erstad, Esper, Eyler, Flordelis Lasierra, Glauber, Greenberg, Gélisse, Hadidi, Hertzog, Hraiech, Hynynen, Johnston, Kawada, Kim, Koster, Krueger, Lamarche, Latronico, Lemaitre, Levison, Malfertheiner, Mehta, Michelle Peahota, Moore, Mousavi, Mulla, Mulla, Muntean, Oliver, Paden, Park, Perkins, Peters, Pettignano, Phillips, Pieri, Potter, Preston, Protti, Ranucci, Riker, Roberts, Roos, Rosen, Ruiz, Rybak, Saini, Sanfilippo, Satyapriya, Schmith, Shekar, Shekar, Shekar, Shekar, Shekar, Sherwin, Sklar, Smith, Spriet, Staudacher, Strunk, Subramaniam, Szefner, Tellor, Trudzinski, Tulman, Turner, Veinstein, Vilay, Wagner, Walter K. Kraft, Welsch, Wen, Wildschut, Wu, Young   +99 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Selective Use of Pericardial Window and Drainage as Sole Treatment for Hemopericardium from Penetrating Chest Trauma [PDF]

, 2018
Background Penetrating cardiac injuries (PCIs) are highly lethal, and a sternotomy is considered mandatory for suspected PCI. Recent literature suggests pericardial window (PCW) may be sufficient for superficial cardiac injuries to drain hemopericardium
Chestovich, Paul J., MD, Clark, Esmeralda, Fildes, John J., Fraser, Douglas R., Kuhls, Deborah A., McNicoll, Christopher F., Patel, Purvi P.   +6 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Detecting early physiologic changes through cardiac implantable electronic device data among patients with COVID-19

Cardiovascular Digital Health Journal, 2022
Background: Cardiac implantable electronic devices (CIEDs) may enable early identification of COVID-19 to facilitate timelier intervention. Objective: To characterize early physiologic changes associated with the onset of acute COVID-19 infection, as ...
Meghan Reading Turchioe, PhD, MPH, RN, Rezwan Ahmed, PhD, Ruth Masterson Creber, PhD, MSc, RN, Kelly Axsom, MD, Evelyn Horn, MD, Gabriel Sayer, MD, Nir Uriel, MD, Kenneth Stein, MD, FHRS, David Slotwiner, MD, FHRS   +8 more
doaj   +1 more source

3-Dimensional Physiologic Postural Range of the Mandible: A Computerized-Assisted Technique—A Case Study

Case Reports in Medicine, 2013
Previous studies demonstrated that while the mandible assumes its resting position in space, antagonistic muscles should assume minimal muscle activity within a spatial range.
Todd Shewman
doaj   +1 more source