Results 111 to 120 of about 8,356,133 (342)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

The Monitor and the Navy under Steam [PDF]

, 1901
Hannis Taylor, Ira N. Hollis, Frank M. Bennett   +2 more
openalex   +1 more source

ERM Quarterly, Quarter 1, April 2015 [PDF]

, 2015
In this issue • Restructuring support measures in focus: Supporting access to finance • Case in focus: Job creation at Deutsche Post DHL • Sector in focus: Job loss at Poczta ...
Eurofound, European Monitoring Centre on Change, European Restructuring Monitor   +2 more
core   +2 more sources

Intelligent optical performance monitor using multi-task learning based artificial neural network

, 2018
An intelligent optical performance monitor using multi-task learning based artificial neural network (MTL-ANN) is designed for simultaneous OSNR monitoring and modulation format identification (MFI).
Shu, * Liang, Wan, Zhiquan, Xu, Kun, Yu, Zhenming, Zhang, Haojie, Zhao, Yilun   +5 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Determination of Heavy Metals in Raw Milk Produced in Tangshan City, China

MATEC Web of Conferences, 2016
The objective of this study was to investigate the content of heavy metals (Arsenic, Lead, Chromium and Mercury) in raw milk of Tangshan. Samples were obtained directly from dairy farms in Tangshan City.
Li Aijun, Du Ruihuan, Zheng Baiqin, Meng Junli, Zhang Jianmin, Xiang Aili, Zhang Xin, Qi Biao, Wu Ying, Zhou Xin, Zhang Yi, Dong Lixue, Pang Xueliang   +12 more
doaj   +1 more source

Machine Features for a More Automatic Monitoring System on Digital Computers [PDF]

, 1957
Charles J. Swift
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Summary of Coastal and Estuarine Monitoring Programs in New Hampshire (2004), Trowbridge, P [PDF]

, 2004
The New Hampshire Estuaries Project (NHEP) compiles data from many coastal and estuarine monitoring programs to assess the status and trends of environmental indicators in the Great Bay and Hampton/Seabrook Harbor.
PREP
core   +1 more source