Results 101 to 110 of about 4,280,969 (314)

Marine Monitoring Program: Annual report for inshore coral reef monitoring 2018–19 [PDF]

open access: yes, 2021
This project is supported by the Great Barrier Reef Marine Park Authority through funding from the Marine Monitoring Program, and the Australian Institute of Marine Science[Extract] This report details the condition of 31 inshore coral reefs monitored ...
Costello, P.   +4 more
core  

An update to the global Critical Habitat screening layer

open access: yesScientific Data
The International Finance Corporation (IFC) defines Critical Habitat in Performance Standard 6 (PS6) as high biodiversity value areas requiring net biodiversity gain for projects.
Sebastian Dunnett   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Community report from the Autism and Developmental Disabilities Monitoring (ADDM) [PDF]

open access: yes
CDC's National Center on Birth Defects and Developmental Disabilities has been tracking ASDs for over a decade through the Autism and Developmental Disabilities Monitoring (ADDM) Network.
National Center on Birth Defects and Developmental Disabilities (Centers for Disease Control and Prevention)
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Arctic Ocean Acidification 2013: An Overview

open access: yes, 2014
Report presenting a summary of the first comprehensive assessment of Arctic Ocean acidification (AOA) conducted by the Arctic Monitoring and Assessment Programme (AMAP).
Arctic Monitoring and Assessment Programme
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Snow, Water, Ice, and Permafrost in the Arctic (SWIPA): Climate Change and the Cryosphere

open access: yes, 2011
Report presenting the findings of the Snow, Water, Ice and Permafrost in the Arctic (SWIPA): Climate Change and the Cryosphere assessment performed by the Arctic Monitoring and Assessment Programme (AMAP) in close cooperation with the International ...
Arctic Monitoring and Assessment Programme
core  

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