Results 111 to 120 of about 4,280,969 (314)

Screening of chlorine-resistant bacteria and investigation of biofilm formation potential in seawater desalination system

Gongye shui chuli
Biofilm, as the main carrier of microbial communities, seriously affects the normal operation of reverse osmosis systems and subsequent water safety. Understanding the potential for biofilm formation and chlorine resistance of chlorine tolerant bacteria ...
REN Kaijia, LIU Siyu, MING Hongxia, LANG Xianlong, SHI Tingting, SU Jie, FAN Jingfeng   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Genetic monitoring of crops and crop wild relatives

, 2007
Durch regelnde Eingriffe des Staates kann genetische Diversität in landwirtschaftlichen Nutzungssystemen erhöht werden. Zur Beurteilung der Wirkung regelnder Eingriffe auf die räumliche Struktur und die zeitliche Entwicklung genetischer Diversität in ...
Frese, Lothar, Vögel, Rudolf, Harrer, Siegfried   +2 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Structural health monitoring of high voltage electrical switch ceramic insulators in seismic areas [PDF]

, 2014
High voltage electrical switches are crucial components to restart rapidly the electrical network right after an earthquake. But there currently exists no automatic procedure to check if these ceramic insulators have suffered after an earthquake, and ...
BARTHES, Clément, MECHBAL, Nazih, Barthes, Clement B., MOSALAM, Khalid M., RÉBILLAT, Marc   +4 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Monitoring education reform in the OECS: A monitoring model and core education indicators

, 2000
This document is based on a workshop on “Monitoring Education Reform in the OECS”, which was held during the 1-3 November, 1999. After describing the workshop process, the OECS Education Monitoring Model is presented, and definitions are provided for the
OECS Education Reform Unit, Meier, Werner, Woodley, Monica   +2 more
core  

Environmental Monitoring

, 2011
"Environmental Monitoring" is a book designed by InTech - Open Access Publisher in collaboration with scientists and researchers from all over the world.

core   +1 more source

Satellite-Detected Anomalous Changes in Parameters of Various Geophysical Fields During Earthquakes of 6 ≤ M ≤ 7.8 in Türkiye in February 2023

Russian Journal of Earth Sciences
Research was conducted using satellite data to study variations in parameters of various geophysical fields manifested in the lithosphere, atmosphere, and ionosphere during the preparation and occurrence of destructive earthquakes of 6 ≤ M ≤ 7.8 in ...
Bondur Valeriy, Tsidilina Marina, Efremycheva Elena, Voronova Olga, Gaponova Mariya, Feoktistova Natalya, Zima Alla   +6 more
doaj   +1 more source