Results 81 to 90 of about 12,264,579 (389)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Welding monitoring system [PDF]
, 1987 This invention relates to systems for remotely monitoring automatic welding operations, and more particularly to a system wherein the welder is readily positionable, while components of the optical system remain fixed.
Babcock, Stephen G. +2 more
core +1 more source
Interpretation of partial discharge activity in the presence of harmonics [PDF]
, 2010 Recent work has identified that circumstances of equipment operation can radically change condition monitoring data. This contribution investigates the significance of considering circumstance monitoring on the diagnostic interpretation of such condition
Bahadoorsingh, S. +4 more
core +1 more source
Haiyang Kaifa yu guanli, 2022 In order to promote the ecological environment protection and ecological disaster control of Yellow Sea, this paper analyzed the background of ecological environment and problems, and put forward suggestions for the construction of regional monitoring ...
Xiaocheng WANG +10 more
doaj
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
, 2010 Herring play a vital role in the North Atlantic ecosystem—serving as food for tuna, cod, striped bass, seabirds, dolphins and whales. But herring and their predators are threatened by industrial-scale fishing by midwater trawlers.
core
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Monitoring extensions for component-based distributed software [PDF]
, 2000 This paper defines a generic class of monitoring extensions to component-based distributed enterprise software. Introducing a monitoring extension to a legacy application system can be very costly.
Diakov, Nikolay K. +2 more
core +3 more sources