Results 101 to 110 of about 540,107 (356)

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

The reactivation of somatosensory cortex and behavioral recovery after sensory loss in mature primates

Frontiers in Systems Neuroscience, 2014
In our experiments, we removed a major source of activation of somatosensory cortex in mature monkeys by unilaterally sectioning the sensory afferents in the dorsal columns of the spinal cord at a high cervical level.
Hui-Xin eQi, Jon H Kaas, Jamie L Reed
doaj   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

B-Virus and Free-Ranging Macaques, Puerto Rico

Emerging Infectious Diseases, 2004
In Puerto Rico, risk for transmission of B-virus from free-ranging rhesus monkeys to humans has become a serious challenge. An incident with an injured rhesus monkey, seropositive for B-virus, resulted in inappropriate administration of antiviral ...
Kristen Jensen, Francisco Alvarado-Ramy, Janis González-Martínez, Edmundo Kraiselburd, Johnny Rullán   +4 more
doaj   +1 more source

Automated Test Input Generation for Android: Are We There Yet?

, 2015
Mobile applications, often simply called "apps", are increasingly widespread, and we use them daily to perform a number of activities. Like all software, apps must be adequately tested to gain confidence that they behave correctly.
Choudhary, Shauvik Roy, Gorla, Alessandra, Orso, Alessandro   +2 more
core   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

Category-specific responses to faces and objects in primate auditory cortex

Frontiers in Systems Neuroscience, 2008
Auditory and visual signals often occur together, and the two sensory channels are known to infl uence each other to facilitate perception. The neural basis of this integration is not well understood, although other forms of multisensory infl uences have
Kari L Hoffman, Kari L Hoffman, Asif A Ghazanfar, Isabel Gauthier, Nikos K Logothetis, Nikos K Logothetis, Nikos K Logothetis   +6 more
doaj   +1 more source

LFP beta amplitude is predictive of mesoscopic spatio-temporal phase patterns

, 2017
Beta oscillations observed in motor cortical local field potentials (LFPs) recorded on separate electrodes of a multi-electrode array have been shown to exhibit non-zero phase shifts that organize into a planar wave propagation.
Brochier, Thomas, Denker, Michael, Diesmann, Markus, Grün, Sonja, Kilavik, Bjørg E., Riehle, Alexa, Zehl, Lyuba   +6 more
core   +4 more sources

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Coding of Velocity Storage in the Vestibular Nuclei

Frontiers in Neurology, 2017
Semicircular canal afferents sense angular acceleration and output angular velocity with a short time constant of ≈4.5 s. This output is prolonged by a central integrative network, velocity storage that lengthens the time constants of eye velocity.
Sergei B. Yakushin, Theodore Raphan, Bernard Cohen   +2 more
doaj   +1 more source