Results 151 to 160 of about 9,605,458 (396)

A Data-Driven Biophysical Computational Model of Parkinson’s Disease Based on Marmoset Monkeys [PDF]

, 2021
Caetano Mazzoni Ranieri, Jhielson M. Pimentel, Marcelo Ramos Romano, Leonardo Abdala Elias, Roseli Aparecida Francelin Romero, Michael A. Lones, Mariana Ferreira Pereira de Araújo, Patrícia A. Vargas, Renan C. Moioli   +8 more
openalex   +1 more source

Low‐intervention clinical trials in Spain: Do they progress?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza, Mayro J. Cortés Pestana, Kristopher Amaro, Rosa M. Antonijoan, Caridad Pontes   +4 more
wiley   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

The influence of the nematode Eustrongylides excisus (Jägerskiöld, 1990) on the body of monkеy goby (Neogobius fluviatilis Pallas, 1814) caught in the lower part of the Dnipro (Zaporizhzhia) Reservoir

Ribogospodarsʹka Nauka Ukraïni
Purpose. To determine the specifics of the influence of the parasitic nematode Eustrongylides excisus on the physiological and biochemical parameters of monkey goby (Neogobius fluviatilis) in the conditions of the lower reach of the Dnipro reservoir ...
V. Sydorenko, O. Marenkov
doaj   +1 more source

Experimental production of respiratory tract disease in cebus monkeys after intratracheal or intranasal infection with influenza A/Victoria/3/75 or influenza A/New Jersey/76 virus [PDF]

, 1978
Michael Grizzard, W. T. London, D. Lewis Sly, B R Murphy, William D. James, W P Parnell, R M Chanock   +6 more
openalex   +1 more source

Gamma Irradiation of Poly(lactide‐co‐glycolide) Scaffolds Reduces the Mechanical Stability and Function of Islet Grafts in Diabetic Nonhuman Primates

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Clinical islet transplantation has long been investigated as a potential cure for type 1 diabetes (T1D), yet standard intrahepatic delivery leaves islets prone to an instant blood‐mediated inflammatory response. Herein, we investigated the design of microporous poly(D,l‐lactide‐co‐glycolide) (PLG) scaffolds for extrahepatic islet ...
Jessica L. King, Christopher Spencer, Richard Youngblood, Kelly Crumley, Elizabeth Bealer, Peter D. Rios, Ira Joshi, Sofia Ghani, Douglas Isa, James J. McGarrigle, David Cook, Conor Locke, Adam Abraham, Andrea Clark, José Oberholzer, Lonnie D. Shea   +15 more
wiley   +1 more source

First evidence of transovarial transmission of Kyasanur Forest disease virus in Haemaphysalis and Rhipicephalus ticks in the wild

Parasites & Vectors
Background Kyasanur forest disease virus (KFDV) is a tick-borne flavivirus causing debilitating and potentially fatal disease in people in the Western Ghats region of India.
Sarah J. Burthe, Bhimanagoud Kumbar, Stefanie M. Schäfer, Bethan V. Purse, Abi T. Vanak, Natrajan Balakrishnan, Richard Hassall, Subhash L. Hoti, Darshan Narayanaswamy, Santoshkumar Potadar, Mujeeb Rahman, Mohammed Mudassar Chanda   +11 more
doaj   +1 more source

Lab‐Scale Continuous Biomanufacturing: A Tool for Process Development With Adaptive Strategies for Capture and Virus Inactivation

Biotechnology and Bioengineering, EarlyView.
Schematic representation of the continuous lab‐scale process. ABSTRACT Monoclonal antibodies (mAbs) are nowadays fundamental in treating a wide range of severe diseases, including cancer, infections, or autoimmune disorders. Due to their high specificity, potent activity, and fewer side effects compared to small molecular drugs, the market for mAbs is ...
Thomas Kruse, Fabian Schmitz, Janina Kilian, Jonas Austerjost, Lucas‐Nik Reger, Markus Kampmann   +5 more
wiley   +1 more source

Levodopa partially rescues microglial numerical, morphological, and phagolysosomal alterations in a monkey model of Parkinson’s disease

, 2020
Cynthia Lecours, Marie‐Kim St‐Pierre, Katherine Picard, Maude Bordeleau, Mélanie Bourque, Ifeoluwa O. Awogbindin, Amin Benadjal, Fernando Gonzàlez Ibáñez, Dave Gagnon, Léo Cantin, Martin Parent, Thérèse Di Paolo, Marie‐Ève Tremblay   +12 more
openalex   +2 more sources

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source