Results 41 to 50 of about 12,509 (169)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Knowledge of monkeypox and willingness to vaccinate against monkeypox among Chinese college students: A cross-sectional study

Journal of Family Medicine and Primary Care
Objective: To investigate the current knowledge level of Chinese college students about monkeypox and their willingness to receive vaccination against monkeypox and to analyze its influencing factors to provide reference for formulating targeted measures
Linqiong Zhou, Hua Fan, Qingwen Yu, Xuhan Tong, Ting Tang, Siqi Hu, Yao You, Shenghui Zhang, Chen Chen, Jiake Tang, Chunyi Wang, Hu Wang, Xinyan Fu, Juan Chen, Xingwei Zhang, Yongran Cheng, Mingwei Wang   +16 more
doaj   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Willingness to accept monkeypox vaccine and its correlates among men who have sex with men in Southern China: a web-based online cross-sectional study

Frontiers in Public Health
BackgroundThe May 2022 global outbreak of monkeypox (MPX) poses a threat to the health of men who have sex with men. However, there is limited data on the willingness of MSM to receive monkeypox vaccination in Southern China.
Xinju Huang, Zhifeng Lin, Jiao Qin, Dee Yu, Fei Zhang, Ganggang Fang, Xi Chen, Jinfeng He, Ping Cen, Mu Li, Rongjing Zhang, Tong Luo, Junjun Jiang, Junjun Jiang, Sanqi An, Sanqi An, Hao Liang, Hao Liang, Li Ye, Li Ye, Bingyu Liang, Bingyu Liang   +21 more
doaj   +1 more source

Probe‐Free, Primer‐Programmed Amplicon Encoding Enables Nanopore‐Based Multiplex Detection With Deep Learning Decoding

Advanced Science, EarlyView.
Primer‐programmed amplicon encoding enables reporter‐probe‐free multiplex nucleic acid identification using glass nanopore sensing and deep neural network decoding. ABSTRACT Single‐reaction multiplex nucleic acid testing (NATs) must both co‐amplify multiple targets and distinguish the resulting amplicons within the product mixture.
Md. Ahasan Ahamed, Muhammad Asad Ullah Khalid, Wahid Uz Zaman, Anthony J. Politza, Weihua Guan   +4 more
wiley   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Monkeypox emergency

New Scientist, 2022
As cases surge, the WHO has raised its alert level and said nations must do more to combat the disease, reports Jason Arunn Murugesu.
openaire   +2 more sources

Human monkeypox — After 40 years, an unintended consequence of smallpox eradication

Frontiers in Public Health, 2023
Monkeypox is one of the many zoonotic viruses that belong to the Orthopoxvirus genus of the Poxviridae family with a similar clinical appearance to smallpox. The symptoms of monkeypox include fever, headache, muscle aches, and lymphadenopathy.
Hussain Haider Shah, Muhammad Khizer Molani, Naqiha Shabbir   +2 more
doaj   +1 more source

Artificial Intelligence in Dermatology: Current Applications and Future Directions

JEADV Clinical Practice, EarlyView.
This scoping review of 56 studies maps AI applications in dermatology. Image‐based classification for skin cancer detection dominates (48%), followed by clinical decision support (21%), teledermatology triage (11%), and predictive analytics (11%). While deep learning algorithms demonstrate diagnostic performance comparable to clinicians in controlled ...
Sofía Pérez‐Lalinde, Francisco Flores   +1 more
wiley   +1 more source

A Comparative Evaluation of Three Diagnostic Assays for the Detection of Human Monkeypox

Viruses
Accurate and early diagnosis of monkeypox virus (MPXV) is crucial for controlling epidemics and treating affected individuals promptly. This study aimed to assess the analytical and clinical performance of the MolecisionTM Monkeypox Virus qPCR Assay ...
Jing Qu, Xiaomin Zhang, Kun Liu, You Li, Ting Wang, Zhonggang Fang, Cheng Chen, Xiao Tan, Ying Lin, Qing Xu, Yan Yang, Wanqing Wang, Manyu Huang, Shiliang Guo, Ziqiu Chen, Wei Rao, Xiaolu Shi, Bo Peng   +17 more
doaj   +1 more source