Results 71 to 80 of about 1,048,226 (221)

Effect of Monkeypox Virus Preparation on the Lethality of the Intravenous Cynomolgus Macaque Model

Viruses, 2022
For over two decades, researchers have sought to improve smallpox vaccines and also develop therapies to ensure protection against smallpox or smallpox-like disease.
Eric M. Mucker, Josh D. Shamblin, Jo Lynne Raymond, Nancy A. Twenhafel, Robert F. Garry, Lisa E. Hensley   +5 more
doaj   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

The Public Health Contribution of Sentiment Analysis of Monkeypox Tweets to Detect Polarities Using the CNN-LSTM Model

Vaccines, 2023
Monkeypox is a rare disease caused by the monkeypox virus. This disease was considered eradicated in 1980 and was believed to affect rodents and not humans.
Orlando Iparraguirre-Villanueva, Aldo Alvarez-Risco, Jose Luis Herrera Salazar, Saul Beltozar-Clemente, Joselyn Zapata-Paulini, Jaime A. Yáñez, Michael Cabanillas-Carbonell   +6 more
doaj   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]

, 2012
Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175), Majzoub Monir, Sutter Gerd, Kay-Martin Hanschmann (181170), Yasemin Suezer, Kalinke Ulrich, Suezer, Yasemin, Monir Majzoub (181167), Yasemin Suezer (181158), Hanschmann Kay-Martin, Theresa Frenz, Melanie Kremer (181155), Michael H. Lehmann (181173), Lehmann Michael H., Suezer Yasemin, Michael H. Lehmann, Volz Asisa, Asisa Volz (181161), Kay-Martin Hanschmann, Michael H Lehmann, Kremer, Melanie, Asisa Volz, Ulrich Kalinke, Hanschmann, Kay-Martin, Kremer Melanie, Kalinke, Ulrich, Theresa Frenz (181164), Monir Majzoub, Sutter, Gerd, Melanie Kremer, Frenz, Theresa, Ulrich Kalinke (41173), Frenz Theresa, Gerd Sutter, Lehmann, Michael H, Volz, Asisa, Majzoub, Monir, Lehmann, Michael H.   +37 more
core   +2 more sources

Medications used in Monkeypox Disease – A Review

Journal of Clinical and Biomedical Sciences
Monkeypox is a zoonotic viral disease similar to smallpox, caused by the monkeypox virus. With the recent global outbreaks, there is an increasing need to understand effective treatments for this infection.
Hebbar J N Arun, N Sarala
doaj   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Monitoring monkeypox virus in saliva and air samples in Spain: a cross-sectional study [PDF]

, 2022
BACKGROUND: The transmission of monkeypox virus occurs through direct contact, but transmission through saliva or exhaled droplets and aerosols has not yet been investigated.
Lagarón Cabello, José María, Prieto López, Cristina, Pardo Figuérez, María, Martín, Rocío, Vergas, Jorge, Alcamí, Antonio, Ayerdi, Oskar, Estrada, Vicente, Cabello, Noemi, del Romero, Jorge, Valls-Carbo, Adrian, Sanchiz, Africa, Hernaez, Bruno, Puerta, Teresa, Vera, Mar, Muñoz-Gómez, Ana, Pardo-Figuerez, María, Negredo, Anabel, Sagastagoitia, Iñigo, Prieto, Cristina, Valls Carbo, Adrian, Orviz, Eva, Lagarón, José María   +22 more
core   +1 more source

Preparedness for a monkeypox outbreak

Infectious Medicine, 2022
In light of the ongoing COVID-19 pandemic, the unexpected outbreak and worldwide spread of monkeypox has gained global attention. As of June 22, 2022, there were 3340 confirmed cases of monkeypox globally, which is the largest and most widespread ...
Qin Luo, Jun Han
doaj   +1 more source

Pietro Verri: The History of Smallpox Vaccination Through His Pencil

JEADV Clinical Practice, EarlyView.
ABSTRACT The last case of natural smallpox infection occurred in 1977, and the disease is considered eradicated since 1980. Throughout the history of medicine, early attempts to combat smallpox involved inoculation, a practice based on the observation that those who recovered from the disease became immune.
Omar Simonetti, Anna Maria Salvadè, Verena Zerbato, Ivo Maria Crosato, Stefano Di Bella, Francesco Bellinato   +5 more
wiley   +1 more source