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Comparative effects of monoamine oxidase inhibitors on monoamine oxidase and diamine oxidase
Biochemical Pharmacology, 1960Abstract The effect of several monoamine oxidase (MAO) inhibitors and related compounds on guinea pig liver MAO and diamine oxidase (DAO) was examined in vitro and after administration to animals. The results showed that the MAO inhibitors possessing the hydrazine moiety inhibited both MAO and DAO, while two phenyl cyclo propylamine MAO inhibitors ...
P A, SHORE, V H, COHN
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Current Protocols in Toxicology, 2000
AbstractMonoamine oxidase catalyzes the oxidative deamination of primary aliphatic and aromatic amines and some secondary and tertiary amines, including the hormone and neurotransmitter amines epinephrine, dopamine, norepinephrine and serotonin. The two isoenzymes, MAO‐A and MAO‐B, differ according to substrate and inhibitor specificities. For example,
Keith F, Tipton +2 more
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AbstractMonoamine oxidase catalyzes the oxidative deamination of primary aliphatic and aromatic amines and some secondary and tertiary amines, including the hormone and neurotransmitter amines epinephrine, dopamine, norepinephrine and serotonin. The two isoenzymes, MAO‐A and MAO‐B, differ according to substrate and inhibitor specificities. For example,
Keith F, Tipton +2 more
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2015
Evidence for the genetic control of human MAO is now well established. The relationships of MAO activities to neuropsychiatric disorders or response to psychopharmacologic treatments are relatively unstudied. Preliminary findings from our own studies suggest that (1) blood MAO activity is a polygenically controlled trait; (2) there may be a subgroup of
D S, Robinson, A, Nies
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Evidence for the genetic control of human MAO is now well established. The relationships of MAO activities to neuropsychiatric disorders or response to psychopharmacologic treatments are relatively unstudied. Preliminary findings from our own studies suggest that (1) blood MAO activity is a polygenically controlled trait; (2) there may be a subgroup of
D S, Robinson, A, Nies
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The Inhibition of Monoamine Oxidase by Esomeprazole [PDF]
Drug Research, 2013 Virtual screening of a library of drugs has suggested that esomeprazole, the S-enantiomer of omeprazole, may possess binding affinities for the active sites of the monoamine oxidase (MAO) A and B enzymes. Based on this finding, the current study examines the MAO inhibitory properties of esomeprazole. Using recombinant human MAO-A and MAO-B, IC50 values
Petzer, A., Pienaar, A., Petzer, J.P.
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Depression and monoamine oxidase
Progress in Neuro-Psychopharmacology, 19791. The first part of the paper is devoted to a critical review on the possible relationships between depression and monoamine oxidase. 2. This study describes the results of an investigation of MAO-activity in depression, using new approaches and methodology.
H, Coper +6 more
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Monoamine oxidases in development
Cellular and Molecular Life Sciences, 2012Monoamine oxidases (MAOs) are flavoproteins of the outer mitochondrial membrane that catalyze the oxidative deamination of biogenic and xenobiotic amines. In mammals there are two isoforms (MAO-A and MAO-B) that can be distinguished on the basis of their substrate specificity and their sensitivity towards specific inhibitors.
Chi Chiu, Wang +4 more
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Acta Physiologica Scandinavica, 1972
AbstractHomogenates of the liver, the kidneys and the brain of the hedgehog, Erinaceus europaeus,. have been tested for monoamine oxidase activity. The enzyme was present in all 3 tissues, and the enzyme was found to act on all the substrates known to be oxidised by other mammalian sources of the enzyme.
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AbstractHomogenates of the liver, the kidneys and the brain of the hedgehog, Erinaceus europaeus,. have been tested for monoamine oxidase activity. The enzyme was present in all 3 tissues, and the enzyme was found to act on all the substrates known to be oxidised by other mammalian sources of the enzyme.
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Monoamine oxidase activity in diabetes
Diabetes, 1983Monoamine oxidase (MAO) activities were measured in platelets from insulin-dependent and non-insulin-dependent diabetic subjects and in platelets from nondiabetic controls. Circulating levels of glycosylated hemoglobin (HbA1) were determined simultaneously. Mean MAO activities were not significantly different in any of these groups.
E, Billett +3 more
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Cannabinoids and monoamine neurotransmission with focus on monoamine oxidase
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2012Progress in understanding the mechanisms of action of cannabinoids was made after discovery of cannabinoid receptors and finding their endogenous ligands. New findings are obtained using both endogenous cannabinoids and plant or synthetic cannabinoids.
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Introductory remarks on monoamine oxidase
Journal of Psychiatric Research, 1974Publisher Summary An enzyme like monoamine oxidase (MAO) may be indirectly involved in a pathological condition of the central nervous system, even if its biosynthesis is not the prime cause of the condition. At present, the role of MAO in the inactivation of dopamine, noradrenaline, and 5-hydroxytryptamine is better understood.
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