Results 1 to 10 of about 80,829 (311)

Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles [PDF]

, 2019
New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B.
Carradori, Simone, Chimenti, Paola, Cirilli, Roberto, Guglielmi, Paolo, Petzer, Anél, Petzer, Jacobus P., Poli, Giulio, Rotondi, Giulia, Secci, Daniela   +8 more
core   +4 more sources

A Stable Tyrosyl Radical in Monoamine Oxidase A [PDF]

Journal of Biological Chemistry, 2004
We present spectroscopic evidence consistent with the presence of a stable tyrosyl radical in partially reduced human monoamine oxidase (MAO) A. The radical forms following single electron donation to MAO A and exists in equilibrium with the FAD flavosemiquinone.
Stephen E. J. Rigby, Robert M.G. Hynson, Rona R. Ramsay, Andrew W. Munro, Nigel S. Scrutton   +4 more
openalex   +4 more sources

Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors

Molecules, 2021
Despite not being utilized as considerably as other antidepressants in the therapy of depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in neurodegeneration and to have a somewhat broad spectrum in respect of the treatment of ...
Tapan Behl, Dapinder Kaur, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Felicia Liana Andronie-Cioara, Mirela Marioara Toma, Simona Bungau, Adrian Gheorghe Bumbu   +9 more
doaj   +1 more source

Molecular docking approach of monoamine oxidase B inhibitors for identifying new potential drugs: Insights into drug-protein interaction discovery [PDF]

Journal of Cell and Molecular Research, 2013
Monoamine oxidase (EC, 1.4.3.4) or amine oxidoreductase catalyzes the oxidative deamination of biogenic amines. Abnormal action of the monoamine oxidase B has been associated with neurological dysfunctions including parkinson´s disorder.
Salimeh Raeisi
doaj   +1 more source

Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity [PDF]

Journal of Neural Transmission, 2013
ISSN:1435 ...
Bartl, Jasmin, Müller, Thomas, Grünblatt, Edna, Gerlach, Manfred, Riederer, Peter   +4 more
openaire   +5 more sources

Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson's disease

eNeurologicalSci, 2020
Background: Dopamine replacement therapy is an established treatment for motor symptoms of Parkinson's disease, but its long-term use is often limited by the eventual development of motor complications, including levodopa-induced dyskinesia.
Shoko Kakinuma, Minako Beppu, Setsu Sawai, Akitoshi Nakayama, Shigeki Hirano, Yoshitaka Yamanaka, Tatsuya Yamamoto, Chigusa Masafumi, Xiamuxiya Aisihaer, Alimasi Aersilan, Yue Gao, Kenichi Sato, Itoga Sakae, Takayuki Ishige, Motoi Nishimura, Kazuyuki Matsushita, Mamoru Satoh, Fumio Nomura, Satoshi Kuwabara, Tomoaki Tanaka   +19 more
doaj   +1 more source

Synthesis and Biological Evaluation of O⁶-Aminoalkyl-Hispidol Analogs as Multifunctional Monoamine Oxidase-B Inhibitors towards Management of Neurodegenerative Diseases

Antioxidants, 2023
Oxidative catabolism of monoamine neurotransmitters by monoamine oxidases (MAOs) produces reactive oxygen species (ROS), which contributes to neuronal cells’ death and also lowers monoamine neurotransmitter levels.
Ahmed H. E. Hassan, Hyeon Jeong Kim, Keontae Park, Yeonwoo Choi, Suyeon Moon, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Min Sung Gee, Danbi Lee, Jong-Hyun Park, Jong Kil Lee, Jong Hoon Ryu, Ki Duk Park, Yong Sup Lee   +14 more
doaj   +1 more source

8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects

Brazilian Journal of Pharmaceutical Sciences, 2020
Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new synthetic coumarin, were ...
María del Pilar Olaya, Nadezdha Esperanza Vergel, Jose Luis López, Dolores Viña, Mario Francisco Guerrero   +4 more
doaj   +1 more source

Allelic Diversity of VNTR Polymorphism in Monoamine Oxidase A (MAOA) Gene in Young Women and Men in Mashhad, Iran

مجله دانشکده پزشکی اصفهان, 2020
Background: Monoamine oxidase A (MAOA) enzyme activity is changed in mood disorders, as well as lower activity associated with criminal and aggressive behaviors.
Sedigheh Sadat Hojjati, Abbas Ali Gaeini, Hadi Rohani, Mohammad Shariatzadeh   +3 more
doaj   +1 more source

Ageing and Neurodegeneration – The Role of Neurotransmitters’ Activity [PDF]

International Journal Bioautomation, 2022
Disease and ageing are linked in many ways and especially by the mechanisms they share. For many diseases, the process of ageing is the main culprit leading to the pathology. Hence, it is crucial to understand the process of ageing, and its molecular and
Bonka Lozanska, Milena Georgieva, George Miloshev, Charilaos Xenodochidis   +3 more
doaj   +1 more source