Results 41 to 50 of about 4,684 (142)

Expression Cloning of a Na+-independent Aromatic Amino Acid Transporter with Structural Similarity to H+/Monocarboxylate Transporters [PDF]

Journal of Biological Chemistry, 2001
A cDNA was isolated from rat small intestine by expression cloning which encodes a novel Na+-independent transporter for aromatic amino acids. When expressed in Xenopus oocytes, the encoded protein designated as TAT1 (T-type amino acid transporter 1) exhibited Na+-independent and low-affinity transport of aromatic amino acids such as tryptophan ...
D K, Kim, Y, Kanai, A, Chairoungdua, H, Matsuo, S H, Cha, H, Endou   +5 more
openaire   +2 more sources

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, Volume 11, Issue 3, Page 1036-1045, June 2026.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source

Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2 [PDF]

FEMS Yeast Research, 2012
We aimed to manipulate the metabolism of Saccharomyces cerevisiae to produce lactic acid and search for the potential influence of acid transport across the plasma membrane in this process. Saccharomyces cerevisiae W303-1A is able to use l-lactic acid but its production in our laboratory has not previously been detected.
António, Pacheco, Gabriel, Talaia, Joana, Sá-Pessoa, Daniela, Bessa, Maria José, Gonçalves, Roxana, Moreira, Sandra, Paiva, Margarida, Casal, Odília, Queirós   +8 more
openaire   +2 more sources

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

British Journal of Pharmacology, Volume 183, Issue 12, Page 3395-3408, June 2026.
In this study, nintedanib reduced lung fibrosis in a rat double‐hit bleomycin‐induced model. Transcriptomic analysis revealed two key gene signatures related to the effect of the molecule: one involving mesenchymal cells affecting known fibrotic pathways and another linking mainly macrophages to lipid metabolism.
Martina Bonatti, Vanessa Pitozzi, Paola Caruso, Silvia Pontis, Maria Gloria Pittelli, Caterina Frati, Denise Madeddu, Federico Quaini, Costanza Anna Maria Lagrasta, Ilaria Minato, Emanuela Bocchi, Maurizio Civelli, Gino Villetti, Marcello Trevisani, Barbara Montanini   +14 more
wiley   +1 more source

Ideal Molecular Sieving with a Dense MOF for Helium Upgrading with Highly Diffusion Selective Mixed Matrix Membranes

Advanced Functional Materials, Volume 36, Issue 43, 29 May 2026.
The separation of Helium gas from natural gas is challenging but highly important. MIL‐116(Ga), a “non‐porous” metal–organic framework is used as a molecular sieve to separate He from CH4. Druse‐like MIL‐116(Ga) particles are integrated into polysulfone mixed matrix membranes.
Ayisha Komal, Laura Calderón‐Rodríguez, Oksana Smirnova, Eren Grossmann, Aparna Binu Varghese, Karen Marlenne Garcia Alvarez, Andreas Schneemann, Thomas Hoyer, Ralf Wyrwa, Felix Helmut Schacher, Alexander Knebel   +10 more
wiley   +1 more source

Unraveling Key Genes Related to Fatty Acid Metabolism in Neuropathic Pain

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Neuropathic pain (NP), a chronic condition resulting from nerve injury or dysfunction, represents considerable therapeutic difficulties owing to its intricate and multifactorial pathophysiology. Recent studies indicate that dysregulated fatty acid metabolism (FAM) plays a pivotal role in the onset and persistence of NP.
Ye Wang, Can Liu, Mingfang Wang, Yuefeng Wang, Yumei Zhou   +4 more
wiley   +1 more source

Acidic drug transport in vivo through the blood-brain barrier. A role of the transport carrier for monocarboxylic acids.

Journal of Pharmacobio-Dynamics, 1990
The relationship of the transports between acidic drugs and monocarboxylic acids through the blood-brain barrier (BBB) was examined using the carotid artery injection technique in rats. The BBB uptakes of [3H]acetic acid and [14C]salicylic acid were significantly reduced by the presence of the respective unlabeled compounds, valproic acid, lactic acid,
KANG, Young, TERASAKI, Tetsuya, TSUJI, Akira   +2 more
openaire   +3 more sources

Crystal Facets Reactivity in Metal–Organic Frameworks

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
In this mini review, it is highlighted how the crystal facets reactivity of metal–organic frameworks can be dictated by bond strength, surface functionality, particle size, defect density, or crystal morphology. Precise control of these parameters enables deliberate exposure of crystal facets, leading to enhanced crystal surface accessibility and ...
Emilio Borrego‐Marin, Jorge A. R. Navarro   +1 more
wiley   +1 more source

Participation of Monocarboxylic Anion and Bicarbonate Exchange System for the Transport of Acetic Acid and Monocarboxylic Acid Drugs in the Small Intestinal Brush-Border Membrane Vesicles.

Journal of Pharmacobio-Dynamics, 1991
A participation of bicarbonate exchange system for the transport of acetic acid and the related monocarboxylic acid drugs in the intestinal brush-border membrane vesicles (BBMVs) was investigated. The uptake of [3H]acetic acid at 37 degrees C by BBMVs was markedly stimulated and showed a clear overshoot phenomenon in the presence of outward-directed ...
SIMANJUNTAK, Matheus, TERASAKI, Tetsuya, TAMAI, Ikumi, TSUJI, Akira   +3 more
openaire   +3 more sources

Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4)

Archives of Biochemistry and Biophysics, 2016
Ferulic acid is released by microbial hydrolysis in the colon, where butyric acid, a major by-product of fermentation, constitutes the main energy source for colonic enterocytes. We investigated how varying concentrations of this short chain fatty acid may influence the absorption of the phenolic acid.
Ziegler, K, Kerimi, A, Poquet, L, Williamson, G   +3 more
openaire   +3 more sources