Results 31 to 40 of about 4,684 (142)
Uptake and Transport of Monotropein and Monotropein Esters in a Caco‐2/HT29‐MTX‐E12 Co‐Culture Model
Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.Monotropein and its naturally occurring ester derivatives (monotropein‐10‐coumarate and monotropein‐10‐cinnamate) from Gaultheria spp. berries exhibit limited intestinal permeability in a validated Caco‐2:HT29‐MTX‐E12 co‐culture model. Absorption occurs predominantly via passive diffusion, with partial SGLT1‐ and OATP‐mediated uptake contribution for ...
Christian Zielinski +7 more
wiley +1 more source
Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality
Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim +3 more
wiley +1 more source
No Evidence for the Involvement of the Multidrug Resistance-Associated Protein and/or the Monocarboxylic Acid Transporter in the Intestinal Transport of Fluvastatin in the Rat. [PDF]
AAPS PharmSci, 2000 Fluvastatin, an amphiphilic anion, shows a nonlinear increase in effective intestinal permeability (P(eff)) with increasing lumenal concentrations in rats. The main objective of this study was to investigate whether or not this observation could be attributed to an efflux-mediated transport by the multidrug resistance-associated protein (MRP).
A, Lindahl +3 more
openaire +2 more sources
Developmental Neurobiology, Volume 86, Issue 3, July 2026.ABSTRACT Rett syndrome is a neurodevelopmental disorder caused by an X‐linked mutation of the MeCP2 gene. Individuals with Rett syndrome, as well as rodent models of this disorder, demonstrate abnormal cortical responses to sound, which impair auditory discrimination ability.
Isabella K. Myers +6 more
wiley +1 more source
Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy
Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva +5 more
wiley +1 more source
Monocarboxylate transporter 1 (MCT1) mediates transport of short‐chain fatty acids in bovine caecum
Experimental Physiology, 2006 The present study was undertaken to investigate the functional role of monocarboxylate transporter 1 (MCT1) in the ruminant large intestine. Messenger RNA encoding for MCT1 was verified by reverse transcriptase‐polymerase chain reaction in caecum, proximal colon and distal colon of adult cattle.
Doaa, Kirat, Seiyu, Kato
openaire +2 more sources
The Plant Journal, Volume 127, Issue 1, July 2026.SUMMARY The Capsicum genus shows remarkable phenotypic diversity, making it an excellent system to study non‐climacteric fruit ripening. Unlike climacteric model species, such as tomato (Solanum lycopersicum), the regulatory networks linking transcriptome and metabolome to fruit quality traits remain poorly understood in non‐climacteric crop species ...
Wesley Elias Bhering Barrios +12 more
wiley +1 more source
Advances in Structural Separation Technologies for Multilayer Packaging Recycling
Advanced Sustainable Systems, Volume 10, Issue 6, June 2026.This review structures the field of multilayer packaging recycling by organizing structural separation technologies by their primary working principles. It compares delamination and selective dissolution‐precipitation across material classes, solvent systems, recovery quality, and industrial readiness.
Aditya Chauhan +2 more
wiley +1 more source
Bombyx mori monocarboxylate transporter 9 (BmMCT9) is involved in the transport of uric acid in silkworm integument [PDF]
Genes to Cells, 2019 AbstractIn Bombyx mori, there are more than 30 mutant strains exhibiting the translucent larval skin resulting from a decrease in the uric acid content in epidermal cell. Of these, the Chinese translucent (oc) mutant presents a moderately translucent larval skin.
Lingyan Wang +7 more
openaire +2 more sources
Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy
BMEMat, Volume 4, Issue 2, June 2026.This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma +9 more
wiley +1 more source