Results 11 to 20 of about 4,684 (142)
The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane [PDF]
Yeast, 2001 AbstractWe have characterized the monocarboxylate permease family of Saccharomyces cerevisiae comprising five proteins. We could not find any evidence that the monocarboxylate transporter‐homologous (Mch) proteins of S. cerevisiae are involved in the uptake or secretion of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane.
Makuc, J +7 more
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Increased Brain Monocarboxylic Acid Transport and Utilization in Type 1 Diabetes [PDF]
Diabetes, 2006 We hypothesized that increased capacity for brain utilization of nonglucose substrates (monocarboxylic acids [MCAs]) by upregulation of the MCA transporters may contribute metabolic substrates during hypoglycemia. To test this hypothesis, we assessed brain acetate metabolism in five well-controlled type 1 diabetic subjects and six nondiabetic control ...
Graeme F, Mason +4 more
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Renal transport of monocarboxylic acids. Heterogeneity of lactate-transport systems along the proximal tubule [PDF]
Biochemical Journal, 1984 The characteristics of D- and L-lactate transport in luminal-membrane vesicles derived from whole cortex, from the pars convoluta and from the pars recta of rabbit kidney proximal tubule were studied. It was found that uptake of both isomers in vesicles from whole cortex occurred by means of dual electrogenic transport systems, namely a low-affinity ...
K E, Jørgensen, M I, Sheikh
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Role of monocarboxylic acid transporters in the cellular uptake of NSAIDs
Journal of Pharmacy and Pharmacology, 2005 Abstract The present study investigated the cellular uptake mechanism of non-steroidal anti-inflammatory drugs (NSAIDs) in Caco-2 cells. Diflunisal, diclofenac, ketoprofen and naproxen exhibited a strong inhibition effect on the cellular uptake of [14C]-benzoic acid in Caco-2 cells with IC50 values of 0.05–0.44 mm.
Jun-Shik, Choi +2 more
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Bioscience, Biotechnology, and Biochemistry, 2006 Phenolic acids such as p-coumaric acid and microbial metabolites of poorly absorbed polyphenols are absorbed by the monocarboxylic acid transporter (MCT)-mediated transport system which is identical to the fluorescein/H(+) cotransport system. We focus here on the physiological impact of MCT-mediated absorption and distribution. We examined whether MCT1,
WATANABE, Hirohito +3 more
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Retinoic Acid Induces Expression of the Thyroid Hormone Transporter, Monocarboxylate Transporter 8 (Mct8) [PDF]
Journal of Biological Chemistry, 2010 Retinoic acid (RA) and thyroid hormone are critical for differentiation and organogenesis in the embryo. Mct8 (monocarboxylate transporter 8), expressed predominantly in the brain and placenta, mediates thyroid hormone uptake from the circulation and is required for normal neural development. RA induces differentiation of F9 mouse teratocarcinoma cells
Takahiko, Kogai +5 more
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Short chain fatty acids and monocarboxylate transporters in irritable bowel syndrome
Turkish Journal of Gastroenterology, 2020 Background/Aims: Gut microbiota ferments indigestible food that rests in the colon to produce short-chain fatty acids (SCFAs) acetate, propionate, and butyrate. Colonic SCFA stimulate the synthesis of serotonin which is central in irritable bowel syndrome (IBS) pathophysiology.
Ernst, Fredericks +2 more
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Monocarboxylate Transporter-Mediated Transport of γ-Hydroxybutyric Acid in Human Intestinal Caco-2 Cells [PDF]
Drug Metabolism and Disposition, 2009 Purpose To evaluate the expression of monocarboxylate transporters (MCTs) 1‐4 and characterize the intestinal transport of the known MCT substrates, γ‐hydroxybutyric acid (GHB) and D‐lactate. Methods The mRNA and protein expression of ...
Wing Ki, Lam +2 more
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Cancer Management and Research, 2023 Tian Liu,1,* Shangcong Han,2,* Yu Yao,1 Guiming Zhang1 1Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao ...
Liu T, Han S, Yao Y, Zhang G
doaj
The Journal of biological chemistry, 1998 Sialic acid and glucuronic acid are monocarboxylated monosaccharides, which are normally present in sugar side chains of glycoproteins, glycolipids, and glycosaminoglycans. After degradation of these compounds in lysosomes, the free monosaccharides are released from the lysosome by a specific membrane transport system.
Havelaar, AC (Adrie) +4 more
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