Results 1 to 10 of about 4,684 (142)
Role of the DHH1 gene in the regulation of monocarboxylic acids transporters expression in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2014 Previous experiments revealed that DHH1, a RNA helicase involved in the regulation of mRNA stability and translation, complemented the phenotype of a Saccharomyces cerevisiae mutant affected in the expression of genes coding for monocarboxylic-acids ...
Sandra Mota +14 more
doaj +9 more sources
Transcriptomic Analysis in the Liver of Two Rabbit Lines Divergently Selected for Intramuscular Fat Content. [PDF]
Anim GenetABSTRACT The intramuscular fat (IMF) content is an important indicator of meat quality, affecting the sensory properties of meat. IMF is a complex trait with polygenic nature. This research aimed to identify differentially expressed (DE) genes and key transcription factors (TFs) associated with IMF deposition in the liver of two rabbit lines ...
Valdés-Hernández J +4 more
europepmc +2 more sources
Uncovering Novel Plasma Membrane Carboxylate Transporters in the Yeast Cyberlindnera jadinii
Journal of Fungi, 2022 The yeast Cyberlindnera jadinii has great potential in the biotechnology industry due to its ability to produce a variety of compounds of interest, including carboxylic acids.
Maria Sousa-Silva +5 more
doaj +1 more source
He huaxue yu fangshe huaxue, 2023 Using α-cyano-4-hydroxy-cinnamic acid, a small molecule inhibitor of monocarboxylic acid transporters(MCTs), as the lead compound, a novel 18F-labeled α-cyano-4-hydroxy-cinnamic acid probe was designed and synthesized.
WANG Hong-liang +5 more
doaj +1 more source
Lactic acid as a systemic product and biomarker of physical load
Біологічні студії, 2023 This paper presents an up-to-date review of research data on the specific features of lactic acid metabolism and its role as an effector of vital regulatory mechanisms. Lactic acid is an alpha-hydroxy monocarboxylic acid.
Yu. R. Boretsky +10 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Proton-coupled monocarboxylate transporters (MCTs), representing the first four isoforms of the SLC16A gene family, mainly participate in the transport of lactate, pyruvate, and other monocarboxylates.
Xiangyu Sun +10 more
doaj +1 more source
The transport mechanism of monocarboxylate transporter on spinosin in Caco-2 cells
Saudi Pharmaceutical Journal, 2016 Objectives: The aim of this study was to determine the uptake mechanism of spinosin (SPI) by the monocarboxylic acid transporters (MCTs) in Caco-2 cells.
Xiang Le Meng +2 more
doaj +1 more source
A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates
Asian Journal of Pharmaceutical Sciences, 2019 Monocarboxylate transporter 1 (MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the development of oral prodrugs.
Yixin Sun +7 more
doaj +1 more source
Proton Transport Chains in Glucose Metabolism: Mind the Proton
Frontiers in Neuroscience, 2018 The Embden–Meyerhof–Parnas (EMP) pathway comprises eleven cytosolic enzymes interacting to metabolize glucose to lactic acid [CH3CH(OH)COOH]. Glycolysis is largely considered as the conversion of glucose to pyruvate (CH3COCOO-). We consider glycolysis to
Dirk Roosterman +2 more
doaj +1 more source
The role of shear stress in Blood-Brain Barrier endothelial physiology
BMC Neuroscience, 2011 Background One of the most important and often neglected physiological stimuli contributing to the differentiation of vascular endothelial cells (ECs) into a blood-brain barrier (BBB) phenotype is shear stress (SS).
Puvenna Vikram +4 more
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