Results 51 to 60 of about 1,828,522 (388)

Monoclonal Antibodies

Dermatologic Clinics, 2015
Use of monoclonal antibodies (mAbs) has revolutionized cancer therapy. Approaches targeting specific cellular targets on the malignant cells and in tumor microenvironment have been proved to be successful in hematologic malignancies, including cutaneous lymphomas.
openaire   +2 more sources

The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group

Nature Reviews Nephrology, 2018
The term monoclonal gammopathy of renal significance (MGRS) was introduced by the International Kidney and Monoclonal Gammopathy Research Group (IKMG) in 2012.
N. Leung, F. Bridoux, V. Batuman, A. Chaidos, P. Cockwell, V. D’Agati, A. Dispenzieri, F. Fervenza, J. Fermand, S. Gibbs, J. Gillmore, G. Herrera, A. Jaccard, D. Jevremovic, E. Kastritis, V. Kukreti, R. Kyle, H. Lachmann, C. Larsen, H. Ludwig, G. Markowitz, G. Merlini, P. Mollee, M. Picken, V. Rajkumar, Virginie Royal, P. Sanders, S. Sethi, C. Venner, P. Voorhees, A. Wechalekar, B. Weiss, S. Nasr   +32 more
semanticscholar   +1 more source

Hybrid cell lines producing monoclonal antibodies directed against Treponema [PDF]

, 1985
Continuous hybrid cell lines for producing monoclonal antibodies directed against antigens of Treponema pallidum have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with antigens of Treponema ...
Kettman, John R., Norgard, Michael V.
core   +1 more source

ADHERENCE AND PERSISTENCE TO TREATMENT WITH INFLIXIMAB: ANALYSIS OF A PATIENT SUPPORT PROGRAM COHORT IN BRAZIL [PDF]

Arquivos de Gastroenterologia
Background: Monoclonal antibodies have proven efficacy in the management of several conditions and infliximab (IFX) is one of the most important drugs of the class.
Aniela Bonorino Xexeo Castelo BRANCO, Wilton ARGOLO, Nathalia SANTOS, Gabriela HERNANDEZ, Adriana KAKEHASI, Carlos Walter SOBRADO, Richard MELSHEIMER   +6 more
doaj   +1 more source

Kinetic Characterisation of a Single Chain Antibody against the Hormone Abscisic Acid: Comparison with Its Parental Monoclonal [PDF]

, 2016
A single-chain Fv fragment antibody (scFv) specific for the plant hormone abscisic acid (ABA) has been expressed in the bacterium Escherichia coli as a fusion protein.
A Hayhurst, A Sadanandom, A Wörn, AM Jones, Andrew J. Thompson, Andrew Marsh, B Kazemier, D Missiakas, DG Myszka, DG Myszka, DM Hoover, Ellen R Goldman, George O. Badescu, GM Banowetz, J Messens, J Phillips, J Wigger, LLH Christensen, M Malmqvist, MK Walker-Simmons, O Artsaenko, O Artsaenko, P Jurado, P Martineau, PB Luppa, Q Li, R Mertens, R Raag, R Waadt, Richard M. Napier, S Shaki-Loewensteina, SA Quarrie, SA Quarrie, SM Kipriyanova, Timothy R. Smith, TR Smith, UL Jönsson, WFM Stöcklein, Y-W Li   +38 more
core   +5 more sources

Dupilumab en el tratamiento del asma

Revista Alergia México, 2021
Dupilumab es un anticuerpo monoclonal humano contra receptores de interleucina (IL)-4 e IL-4/IL-13. Estas son citocinas clave en la génesis de la inflamación tipo 2, predominante en los pacientes con asma. Los ensayos clínicos que evalúan la eficacia de
Said Eduardo Arablin-Oropeza, Víctor González-Uribe, Blanca E. Del Río-Navarro, Ana del Carmen García-González, Elsy M. Navarrete-Rodríguez, Alberto Valencia   +5 more
doaj   +1 more source

The monoclonal gammopathies

Clinical Chemistry, 1994
Abstract Each monoclonal protein (M-protein, or myeloma protein) consists of two heavy polypeptide chains of the same class and subclass and two light polypeptide chains of the same type. Electrophoresis on cellulose acetate membranes is satisfactory for screening, although agarose electrophoresis is more sensitive for detecting small M ...
openaire   +3 more sources

Tumor necrosis factor inhibitors in psoriatic arthritis. [PDF]

, 2017
INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially.
Kraft, Walter K., Mantravadi, Santhi, Ogdie, Alexis   +2 more
core   +2 more sources

T-Cell Dependent Immunogenicity of Protein Therapeutics Pre-clinical Assessment and Mitigation–Updated Consensus and Review 2020

Frontiers in Immunology, 2020
Immune responses to protein and peptide drugs can alter or reduce their efficacy and may be associated with adverse effects. While anti-drug antibodies (ADA) are a standard clinical measure of protein therapeutic immunogenicity, T cell epitopes in the ...
Vibha Jawa, Frances Terry, Jochem Gokemeijer, Shibani Mitra-Kaushik, Brian J. Roberts, Sophie Tourdot, Anne S. De Groot, Anne S. De Groot   +7 more
doaj   +1 more source

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
DJ Garry, GF Bottazzo, GF Bottazzo, GS Eisenbarth, J Satoh, MA Atkinson, MR Christie, P Casali, PG Colman, R Gianani, RC Nayak, RJ Tuson, RL Sorenson, S Baekkeskov, S Baekkeskov, S Genovese, W Richter, W Richter, W Richter, WA Scherbaum   +19 more
core   +1 more source