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Monoclonal B-cell lymphocytosis: a reappraisal of its clinical implications

Leukemia and Lymphoma, 2012
Monoclonal B-cell lymphocytosis (MBL) is a recently defined medical condition that displays biological similarities to chronic lymphocytic leukemia (CLL), the most common subtype of adult leukemia in the Western world. MBL may be diagnosed in individuals
Matteo Molica, Ilaria Del Giudice, Roberto Foà   +2 more
exaly   +2 more sources

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The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors

British Journal of Haematology, 2009
Francesco Bertoni, Valter Gattei, Davide Rossi   +2 more
exaly   +2 more sources

Monoclonal B-cell lymphocytosis, monoclonal gammopathy of undetermined significance, and T-cell clones of uncertain significance: are these premalignant conditions sharing a common identity?

The Lancet Haematology, 2023
Monoclonal B-cell lymphocytosis, monoclonal gammopathy of undetermined significance, and T-cell clones of uncertain significance are three premalignant conditions characterised by the presence of small clonal cell expansions in individuals without ...
G. Semenzato, I. Ghobrial, P. Ghia
semanticscholar   +1 more source

Overview of monoclonal B-cell lymphocytosis

British Journal of Haematology, 2007
Monoclonal B-cell lymphocytosis (MBL) has been the subject of more intensive investigation for the last 10 years. The increased presence of MBL in unaffected, first-degree relatives with familial chronic lymphocytic leukaemia (CLL) suggest that it is ...
Andy C Rawstron, Paolo Ghia, Thérèse Aurran   +2 more
exaly   +2 more sources

The role of imaging studies in predicting time to first treatment and overall survival in high‐count monoclonal B‐cell lymphocytosis

British Journal of Haematology
In individuals with high‐count monoclonal B‐cell lymphocytosis (MBL), we investigated if lymphadenopathy or splenomegaly found by imaging was associated with shorter time to first chronic lymphocytic leukaemia (CLL) therapy (TTFT) and overall survival ...
S. Kosydar, W. Archibald, P. Hampel, T. Call, S. Achenbach, K. Rabe, C. Hanson, A. Koehler, Eli Muchtar, Saad S. Kenderian, J. Leis, Yu-Cai Wang, Lindsey E. Roeker, Talal Hilal, M. Tsang, Ricardo D. Parrondo, E. Braggio, Min Shi, S. Schwager, S. Slager, Neil E. Kay, S. Parikh   +21 more
semanticscholar   +1 more source

Monoclonal B-cell lymphocytosis: Does the elderly patient need a specialistic approach?

European Journal of Internal Medicine, 2018
Monoclonal B-cell lymphocytosis (MBL) is defined by the presence of a monoclonal B-cell population in the peripheral blood (PB) at a concentration of
Lydia Scarfò, Paolo Ghia, Piera Angelillo   +2 more
exaly   +2 more sources

Serum Immunoglobulins Are an Independent Prognostic Marker of Time to First Therapy in Newly Diagnosed Chronic Lymphocytic Leukemia (CLL) and Monoclonal B-Cell Lymphocytosis (MBL)

Blood
Background: Immune dysfunction is a hallmark of chronic lymphocytic leukemia (CLL), and several studies suggest that hypogammaglobulinemia at the time of CLL diagnosis may predict shorter time to first therapy (TTFT; Parikh et al, 2015).
Yuan Yao, K. Rabe, C. Allmer, G. Kleinstern, N. Boddicker, Shulan Tian, L. Bruins, D. R. O'Brien, Aaron D. Norman, Hui-Huang Yan, T. Call, Paul J. Hampel, Yu-Cai Wang, Eli Muchtar, S. Kenderian, Neil E. Kay, Celine M. Vachon, J. Cerhan, S. Slager, E. Braggio, S. Parikh   +20 more
semanticscholar   +1 more source

The predictive value of mosaic chromosomal alterations for lymphoid malignancies varies by monoclonal B-cell lymphocytosis status

Blood
Mosaic chromosomal alterations (mCAs) are large-scale somatic gains, losses, or copy-neutral loss of heterozygosity (CNLOH) detectable by genotyping of peripheral blood DNA.
Rosalie Griffin, T. Shanafelt, S. Parikh, N. Boddicker, Kari G. Rabe, C. Allmer, A. Norman, Yuan Yao, Bryan A. Vallejo, Stacey J. Lehman, Janet Olson, Yu-Cai Wang, Lindsey E. Roeker, Paul J. Hampel, E. Braggio, M. Patnaik, Celine M. Vachon, J. Cerhan, C. Hanson, S. Slager   +19 more
semanticscholar   +1 more source

Long-term event-free survival in patients with IGHV-mutated high-count monoclonal B-cell lymphocytosis and atypical, non-CLL-like phenotypes

Blood
Monoclonal B-cell lymphocytosis (MBL) is a frequent precursor of chronic lymphocytic leukemia (CLL) and among the most common premalignant hematologic conditions.
J. Bohn, Stephanie Grabenwarter, Leilu Mangold, Martyna Bartkowiak, Katrin Schweneker, G. Hoermann, N. Steiner, M. Hoechstetter, T. Haferlach, C. Wendtner, Dominik Wolf   +10 more
semanticscholar   +1 more source

Paroxysmal cold hemoglobinuria associated with monoclonal b-cell lymphocytosis in an elderly patient: A rare case report

Blood
Introduction: Paroxysmal cold hemoglobinuria (PCH) is a rare cause of autoimmune hemolytic anemia (AIHA), most frequently observed in children following viral infections.
Summiya Nasim, Matthew Bartock
semanticscholar   +1 more source