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Monoclonal gammopathy of undetermined significance
British Journal of Haematology, 2006A 58-year-old man with no significant medical history is found to have an elevated total protein concentration (8.1 g per deciliter) on a routine blood chemical study. He is asymptomatic, and his physical examination is normal. Serum protein electrophoresis reveals a monoclonal spike of 2.1 g per deciliter at the gamma region; immunofixation shows a ...
Robert A Kyle, S Vincent Rajkumar
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Monoclonal Gammopathy of Undetermined Significance
Annals of Internal Medicine, 2022Monoclonal gammopathy of undetermined significance (MGUS) is of considerable clinical importance to primary care physicians given its high prevalence in the general population. MGUS has a variable but lifelong risk for progression to hematologic cancer, such as multiple myeloma, Waldenström macroglobulinemia, or light-chain amyloidosis.
Wilson I. Gonsalves, S. Vincent Rajkumar
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Monoclonal Gammopathy of Undetermined Significance
British Journal of Haematology, 2005SummarySignificant advances have been made in our understanding of the natural history, pathogenesis, mechanisms of progression and prognosis of monoclonal gammopathy of undetermined significance (MGUS). Although the overall incidence of MGUS progression is 1 per year, it is now possible to more accurately predict the risk of progression based on a new
Robert A, Kyle, S Vincent, Rajkumar
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Prevalence of Monoclonal Gammopathy of Undetermined Significance
New England Journal of Medicine, 2006The prevalence of monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma-cell disorder, among persons 50 years of age or older has not been accurately determined. We used sensitive laboratory techniques to ascertain the prevalence of MGUS in a large population in a well-defined geographic area.We identified all living ...
Robert A, Kyle +8 more
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Monoclonal gammopathies of undetermined significance: a review
Immunological Reviews, 2003Summary: Monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of a monoclonal protein (M‐protein) in patients without evidence of multiple myeloma (MM), macroglobulinemia, amyloidosis (AL), or a related plasma cell proliferative disorder.
Robert A, Kyle, S Vincent, Rajkumar
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[Monoclonal gammopathy of undetermined significance].
Ugeskrift for laeger, 2021This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of
Niels Emil Ulrich, Hermansen +4 more
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Prognosis in monoclonal gammopathy of undetermined significance
British Journal of Haematology, 1997Eighty‐seven patients with monoclonal gammopathy of undetermined significance (MGUS) were followed for a period of 1–20 years, median 91 months. Transformation to multiple myeloma occurred in 14 patients of whom seven died as a consequence of the disease. There were 13 unrelated deaths.
Vučković, Joško +5 more
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Monoclonal Gammopathy of Undetermined Significance
The American Journal of Medicine, 1978Monoclonal gammopathy of undetermined significance (MGUS) accounted for 56% of the 1026 patients with a monoclonal plasma cell disorder seen at the Mayo Clinic during 1992. Approximately 3% of persons older than 70 years and 1% of those older than 50 years had MGUS.
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Monoclonal gammopathies of undetermined significance
La Revue du praticien, 2006Monoclonal gammopathies of undetermined significance constitute a body of asymptomatic diseases characterized by a selective increase of a single serum immunoglobulin due to an only dysregulated clone of B lymphocytes. They occur in up to 10% of persons over 80 years of age. The diagnosis is suggested in presence of both M component in serum
Norbert, Ifrah, Marc, Zandecki
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The Undetermined Significance of Screening for Monoclonal Gammopathy of Undetermined Significance
Cancer Epidemiology, Biomarkers & PreventionAbstract The identification of premalignant lesions in solid tumors such as colorectal and cervical cancer has led to the development of highly effective population-wide screening programs for these malignancies.
Lindor Qunaj +2 more
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