Results 211 to 220 of about 15,402 (239)
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Monoclonal Gammopathy of Undetermined Significance
New England Journal of Medicine, 2007Monoclonal gammopathy of undetermined significance (MGUS) is a precancerosis comprising two different kinds of cancer: lymphoid/lymphoplasmocytoid MGUS and plasma cell MGUS that represents about 85% of all MGUS cases. This type of MGUS has low but persistent tendency to transform to malignant disease, mainly multiple myeloma (MM), with frequency of ...
MINISOLA, Salvatore +2 more
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[Monoclonal gammopathy of undetermined significance].
Ugeskrift for laeger, 2021This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of
Niels Emil Ulrich, Hermansen +4 more
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Monoclonal Gammopathy of Undetermined Significance
British Journal of Haematology, 2005SummarySignificant advances have been made in our understanding of the natural history, pathogenesis, mechanisms of progression and prognosis of monoclonal gammopathy of undetermined significance (MGUS). Although the overall incidence of MGUS progression is 1 per year, it is now possible to more accurately predict the risk of progression based on a new
Robert A, Kyle, S Vincent, Rajkumar
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[Monoclonal gammopathies of undetermined significance].
La Revue du praticien, 2006Monoclonal gammopathies of undetermined significance constitute a body of asymptomatic diseases characterized by a selective increase of a single serum immunoglobulin due to an only dysregulated clone of B lymphocytes. They occur in up to 10% of persons over 80 years of age. The diagnosis is suggested in presence of both M component in serum
Norbert, Ifrah, Marc, Zandecki
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Monoclonal Gammopathy of Undetermined Significance
The American Journal of Medicine, 1978Monoclonal gammopathy of undetermined significance (MGUS) accounted for 56% of the 1026 patients with a monoclonal plasma cell disorder seen at the Mayo Clinic during 1992. Approximately 3% of persons older than 70 years and 1% of those older than 50 years had MGUS.
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Prevalence of Monoclonal Gammopathy of Undetermined Significance
New England Journal of Medicine, 2006The prevalence of monoclonal gammopathy of undetermined significance (MGUS), a premalignant plasma-cell disorder, among persons 50 years of age or older has not been accurately determined. We used sensitive laboratory techniques to ascertain the prevalence of MGUS in a large population in a well-defined geographic area.We identified all living ...
Robert A, Kyle +8 more
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NEUROPATHIES OF MONOCLONAL GAMMOPATHIES OF UNDETERMINED SIGNIFICANCE
Hematology/Oncology Clinics of North America, 1999Although rare, MGUS neuropathies offer a unique glimpse of some the molecular mechanisms of autoimmunity. For this reason alone, they are important disorders and are being studied vigorously in many research centers around the world. In at least some cases, they are potentially treatable.
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[Monoclonal gammopathies of undetermined significance].
La Revue de medecine interne, 2001Monoclonal gammopathy of undetermined significance is an asymptomatic disorder associated with serum monoclonal immunoglobulin spike. Its incidence is about 1% in patients of 50 years of age, and rapidly increases in elderly patients.Within the 20 years following diagnosis, about 25% of patients will evolve towards either multiple myeloma (for patients
M, Zandecki +3 more
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Monoclonal Gammopathy of Undetermined Significance
New England Journal of Medicine, 2006A 58-year-old man with no significant medical history is found to have an elevated total protein concentration (8.1 g per deciliter) on a routine blood chemical study. He is asymptomatic, and his physical examination is normal. Serum protein electrophoresis reveals a monoclonal spike of 2.1 g per deciliter at the gamma region; immunofixation shows a ...
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Monoclonal gammopathies of undetermined significance: a review
Immunological Reviews, 2003Summary: Monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of a monoclonal protein (M‐protein) in patients without evidence of multiple myeloma (MM), macroglobulinemia, amyloidosis (AL), or a related plasma cell proliferative disorder.
Robert A, Kyle, S Vincent, Rajkumar
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