Results 181 to 190 of about 2,735 (209)

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

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Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio in depression: A meta-analysis

Journal of Affective Disorders, 2022
The possible associations between depression and neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR) have been evaluated in numerous studies. But the results were still controversial.The WEB OF SCIENCE, PUBMED, EMBASE, and COCHRANE LIBRARY databases were searched for eligible studies ...
Mi, Su, Xiaoxiao, Ouyang, Yongyan, Song
exaly   +3 more sources

Monocyte-to-lymphocyte ratio predicts mortality and cardiovascular mortality in the general population

International Journal of Cardiology, 2023
Systemic chronic inflammation (SCI) is closely involved in the pathogenesis of many diseases. This study aims to investigate the association between MLR with mortality and cardiovascular disease (CVD) mortality in US adults.35,813 adults were enrolled from the 1999-2014 National Health and Nutrition Examination Survey (NHANES) cycle.
Xiang-Qing Kong, Jin-Yu Sun
exaly   +3 more sources

Monocyte‐to‐lymphocyte, neutrophil‐to‐lymphocyte and neutrophil‐to‐monocyte plus lymphocyte ratios in children with active tuberculosis: A multicentre study

Acta Paediatrica, 2023
AbstractAimHigher number of monocytes and neutrophils may correlate with active tuberculosis (TB) in children. However, the few paediatric studies available are limited by the small numbers of children with TB disease or infection included.MethodsWe calculated the monocyte‐to‐lymphocyte‐ratio (MLR), neutrophil‐to‐lymphocyte‐ratio (NLR) and neutrophil ...
Cursi, Laura, Lancella, Laura, Mariani, Francesco, Martino, Laura, Leccese, Bianca, Di Giuseppe, Martina, Venuti, Francesco, Cristina, Russo, Gentile, Leonarda, Sali, Michela, Delogu, Giovanni, Valentini, Piero, Buonsenso, Danilo   +12 more
openaire   +4 more sources

Relationship between monocytes to lymphocytes ratio and axial spondyloarthritis

International Immunopharmacology, 2018
Axial spondyloarthritis (axSpA) is a progressive, chronic, inflammatory skeletal disorder affecting the spine and sacroiliac joints. Many studies have shown that neutrophils, lymphocytes, monocytes, platelets, and red blood cells (RBCs) play important roles in the inflammatory process of axSpA.
Yukai, Huang, Weiming, Deng, Shaoling, Zheng, Fan, Feng, Zhixiang, Huang, Qidang, Huang, Xin, Guo, Zhengping, Huang, Xuechang, Huang, Xia, Pan, Tianwang, Li   +10 more
openaire   +2 more sources

Monocyte-to-Lymphocyte Ratio in Clot Analysis as a Marker of Cardioembolic Stroke Etiology

Translational Stroke Research, 2021
The aim of the study was to find markers of high-risk cardioembolic etiology (HRCE) in patients with cryptogenic strokes (CS) through the analysis of intracranial clot by flow cytometry (FC). A prospective single-center study was designed including patients with large vessel occlusion strokes. The percentage of granulocytes, monocytes, lymphocytes, and
Juega, J, Palacio-Garcia, C, Rodriguez, M, Deck, M, Rodriguez-Luna, D, Requena, M, Garcia-Tornel, A, Rodriguez-Villatoro, N, Rubiera, M, Boned, S, Muchada, M, Ribo, M, Pinana, C, Hernandez, D, Coscojuela, P, Diaz, H, Sanjuan, E, Hernandez-Perez, M, Dorado, L, Quesada, H, Cardona, P, De-la-Torre, C, Tomasello, A, Gallur, L, Sanchez, M, Gonzalez-Rubio, S, Camacho, J, Ramon-Y-Cajal, S, Alvarez-Sabin, J, Molina, CA, Pagola, J   +30 more
openaire   +3 more sources

The meaning of a high monocyte to lymphocyte ratio in tuberculosis

Tuberculosis, 2019
Introduction: Several studies have reported an association between a high monocyte to lymphocyte ratio (ML ratio) and tuberculosis (TB). We did not find the ML ratio to be a useful marker of TB disease, due to low sensitivity and negative predictive value for development of disease (BTS Winter Meeting 2018).
Tom Buttle, Graham Bothamley
openaire   +1 more source

P214 The monocyte to lymphocyte ratio as a biomarker for tuberculosis

Clinical studies in TB and NTM, 2018
Introduction A high ratio of monocytes to lymphocytes (ML ratio) has been associated with tuberculosis (TB) disease. The purpose of our study was to examine the veracity of this association in TB disease and determine the values found in those with latent TB infection (LTBI).
T Buttle, GH Bothamley
openaire   +1 more source