Results 161 to 170 of about 90,200,282 (296)
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang +15 more
wiley +1 more source
Background Early detection of tuberculosis (TB) in children living with HIV (CLHIV) is crucial for improving clinical outcomes and reducing disease transmission. This study aimed to evaluate the association between hematological parameters, including the
Yogesh M +3 more
doaj +1 more source
In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He +20 more
wiley +1 more source
Prognostic impact of peripheral blood ratio in sinonasal squamous cell carcinoma
Objective Sinonasal squamous cell carcinoma usually presents at an advanced stage at the time of diagnosis, and there is still a lack of indicators to predict the prognosis of sinonasal squamous cell carcinoma patients.
Tian Wang +5 more
doaj +1 more source
Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR) and Monocyte-to-Lymphocyte Ratio (MLR) as Biomarkers in Diagnosis Evaluation of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective, Observational Study [PDF]
Chuang Cai,1,* Wentan Zeng,2,* Hongwei Wang,3 Shuqi Ren2 1Cancer Research Institute of Zhongshan City, Zhongshan City People’s Hospital, Zhongshan City, Guangdong Province, People’s Republic of China; 2Department of Laboratory Medicine, Tanzhou ...
Cai C, Wang H, Zeng W, Ren S
core
To better characterize an infusible extracellular matrix (iECM) material, we applied size‐based fractionation to separate out components into two major fractions. We characterized these fractions to understand how material properties such as composition, morphology, and biochemical properties affect bioactive effects in the context of acute myocardial ...
Michael B. Nguyen +13 more
wiley +1 more source
Quantitative phase maps of single cells recorded in flow cytometry modality feed a hierarchical architecture of machine learning models for the label‐free identification of subtypes of ovarian cancer. The employment of a priori clinical information improves the classification performance, thus emulating the clinical application of liquid biopsy during ...
Daniele Pirone +11 more
wiley +1 more source
Clinical diagnostic value of methylated SEPT9 combined with NLR, PLR and LMR in colorectal cancer
Purpose This study aimed to investigate clinical diagnostic values of mSEPT9 combined with NLR, PLR and LMR in CRC. Methods 329 subjects composed of 120 CRC patients, 105 polyps patients and 104 healthy participants were prospectively recruited ...
Meiyuan Huang +7 more
doaj +1 more source
Objective The objective of this study was to explore the association between 18 kDa translocator protein (TSPO)‐positron emission tomography (PET)–measurable glial activation and serum chitotriosidase (CHIT1) in people with multiple sclerosis (pwMS), and its expression in postmortem MS brain tissue.
Venla Ahola +14 more
wiley +1 more source
Objective Quantify cytokines in cerebrospinal fluid (CSF) of virologically suppressed people with HIV (PWH) and people without HIV (PWoH) and correlate these with neuroimaging, neuropsychometric (NP), and neurodegenerative measurements. Methods CSF samples were collected from virologically suppressed PWH and demographically matched PWoH under a natural
Jack Peterson +13 more
wiley +1 more source

