Results 191 to 200 of about 138,183 (374)

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

The Postoperative Lymphocyte to Monocyte Ratio Change Predicts Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Resection [PDF]

, 2020
Qian Song, Junzhou Wu, Huifen Jiang, Sheng Wang, Shunv Cai   +4 more
openalex   +1 more source

Impact on the survival of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and monocyte-lymphocyte ratio on prognosis in children with Hodgkin lymphoma [PDF]

, 2022
Kübra ERTAN, Aysenur Dogru, Buket Kara, Yavuz Köksal   +3 more
openalex   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

The Role of Admission Glucose and Inflammatory Markers in Histopathological Features of Atherosclerotic Plaques in Carotid and Femoro-Popliteal Arteries

Medicina
Background and Objectives: Atherosclerosis is a chronic inflammatory disease significantly contributing to cardiovascular morbidity and mortality. This study primarily aims to evaluate the role of baseline blood glucose levels and inflammatory markers in
Mircea Cătălin Coșarcă, Suzana Vasilica Șincaru, Emőke Horváth, Daniela Tatiana Sala, Nicolae Alexandru Lazăr, Ludovic Alexandru Szanto, Marius Mihai Harpa, Cosmin Carașcă, Gergő Ráduly, Paula Bândea, Vasile Adrian Mureșan   +10 more
doaj   +1 more source

Monocyte–lymphocyte ratio predicts cardiovascular diseases death in individuals with type 2 diabetes [PDF]

Han Li, Yixuan Li, Wenwen Guo, Xinwei Liu, Yuhao Wang, Tianshu Zeng, Wen Kong   +6 more
openalex   +1 more source

The relationship between neutrophil/lymphocyte, monocyte//lymphocyte, platelet/lymphocyte ratios and clinical outcomes after ninety days in patients who were diagnosed as having acute ischemic stroke in the emergency room and underwent a mechanical thro

, 2020
Emre Özgen, Murat Güzel, Çetin Kürşad Akpınar, Murat Yücel, Mehmet Demir, Ahmet Baydın   +5 more
openalex   +2 more sources

Lymphocyte-to-monocyte ratio in colorectal cancer patients [PDF]

, 2017
Zofia Stasik, E. Wójcik, Urszula Rychlik, J. Tarapacz, Wojciech M. Wysocki, Kanty Kulpa Jan   +5 more
openalex   +1 more source

Neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) as biomarkers in diabetic ketoacidosis

Egyptian Pediatric Association Gazette
Abstract Background This study aimed to assess neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) as inflammatory markers in diabetic pediatrics with and without diabetic ketoacidosis (DKA) and to evaluate their DKA diagnostic ability in the absence of infection.
Nada M. Elfeky, Maggie A. Ibrahim, Azza A. Eltayeb, Rania Bakry, Ehsan A. Hassan   +4 more
openaire   +2 more sources

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3 [PDF]

, 2004
INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process.
Bell, A.K., Davies, C.R., Duffy, M.A., Ferrier, R.K., Gusterson, B.A., Heath, V.J., Morris, J.S., Sandilands, G.P., Stein, T., Weber-Hall, S.J.   +9 more
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