Results 231 to 240 of about 451,788 (298)

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Complete Blood Count Parameters and Hemogram-Derived Inflammatory Indices in Adolescent Pregnancy: A Retrospective Comparative Cohort Study with Exploratory Machine-Learning Analyses. [PDF]

J Clin Med
Bekmezci M, Bülbül R, Genç ŞÖ, Erdal H.   +3 more
europepmc   +1 more source

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

Monocyte-to-High-Density-Lipoprotein Ratio Is Associated with Ventricular Arrhythmia in Patients with Implantable Cardioverter-Defibrillators: A Cross-Sectional Study. [PDF]

J Cardiovasc Dev Dis
Küçükukur M, Ekmekçi C.
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Beta-lactam antibiotics have immunomodulatory effects in vitro, including changes consistent with sepsis-induced immunosuppression. [PDF]

Crit Care
Snow TAC, Charoenpong S, Kim H, Carthigesan K, Gallagher L, Elkhodair S, Avraham R, Das A, Singer M, Brealey D, Arulkumaran N, University College London Hospitals Critical Care Research Team.   +11 more
europepmc   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

KDM6B inhibition modulates monocyte activation and alleviates IMQ-induced psoriasis-like skin inflammation. [PDF]

Cell Commun Signal
Damara A, Abassi N, Mihoc D, Nastaranpour M, Kraft P, Sarkar T, Kübelbeck T, Kramer D, Deppermann C, Mayer JU, Grabbe S, Delacher M, Marini F, Shahneh F.   +13 more
europepmc   +1 more source

Discordant Interleukin-27 (IL-27) Subunit Transcription in Human Sepsis Exposes a Molecular-Attribution Gap. [PDF]

Biomedicines
Zhang Y, Sun QS.
europepmc   +1 more source

Modulatory effects of S1QEL on OxLDL-induced metabolic alterations and inflammatory responses in human monocytes. [PDF]

Immunometabolism (Cobham)
Mosalmanzadeh N, Maurmann RM, Davis K, Schmitt BL, Makowski L, Pence BD.   +5 more
europepmc   +1 more source