Results 221 to 230 of about 90,200,325 (293)

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

open access: yesInterdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li   +15 more
wiley   +1 more source

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo   +10 more
wiley   +1 more source

First‐Trimester CBC‐Derived Inflammatory Indices for Prediction of Miscarriage: A Retrospective Cohort Study

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Maternal age was an independent predictor of miscarriage, and first‐trimester NLR and SII provided significant incremental predictive value. Because these indices are routinely derived from standard CBC testing without additional cost, they may serve as practical adjuncts to clinical risk factors for early miscarriage risk stratification.
Suchada Wattanaploy   +2 more
wiley   +1 more source

Elevated monocyte-to-lymphocyte ratio, C-reactive protein and further inflammatory parameters as potential biomarkers of suicide risk in bipolar I disorder. [PDF]

open access: yesFront Psychiatry
Pethő B   +10 more
europepmc   +1 more source

Flow Cytometric Lymphocyte Subset Enumeration for Lymphopenia Grading and C‐Reactive Protein‐Defined Inflammation Discrimination

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
This study refines conventional lymphopenia grading by establishing optimized T‐cell cutoffs via flow cytometric lymphocyte subset profiling. Additionally, by evaluating individual subset performance (CD4+, CD8+, B, and NK cells), the framework integrates these counts to construct predictive models for infection‐associated inflammation.
Shicheng Li   +5 more
wiley   +1 more source

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