Results 21 to 30 of about 1,130,327 (225)

Monogenic Diabetes due to ABCC8/KCNJ11 Mutation: Case Study and Review of Literature [PDF]

, 2020
Monogenic diabetes arises due to mutation in a single-gene and is recognized by their striking familial inheritance pattern. This form of diabetes is inherited in an autosomal dominant or recessive fashion, unlike polygenic Type 1 (autoimmune) or type 2 ...
Wei, C, Bano, G, Karunakaran, V
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Genetic testing for misclassified monogenic diabetes in Māori and Pacific peoples in Aōtearoa New Zealand with early-onset type 2 diabetes

Frontiers in Endocrinology, 2023
AimsMonogenic diabetes accounts for 1-2% of diabetes cases yet is often misdiagnosed as type 2 diabetes. The aim of this study was to examine in Māori and Pacific adults clinically diagnosed with type 2 diabetes within 40 years of age, (a) the prevalence
Zanetta Toomata, Zanetta Toomata, Megan Leask, Megan Leask, Mohanraj Krishnan, Murray Cadzow, Nicola Dalbeth, Lisa K. Stamp, Janak de Zoysa, Tony Merriman, Tony Merriman, Phillip Wilcox, Phillip Wilcox, Ofa Dewes, Ofa Dewes, Ofa Dewes, Rinki Murphy, Rinki Murphy   +17 more
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Diabetes Mellitus Diagnosed in Childhood and Adolescence With Negative Autoimmunity: Results of Genetic Investigation

Frontiers in Endocrinology, 2022
Monogenic diabetes is a rare form of diabetes, accounting for approximately 1% to 6% of pediatric diabetes patients. Some types of monogenic diabetes can be misdiagnosed as type 1 diabetes in children or adolescents because of similar clinical features ...
Marilea Lezzi, Marilea Lezzi, Concetta Aloi, Alessandro Salina, Martina Fragola, Marta Bassi, Marta Bassi, Marina Francesca Strati, Marina Francesca Strati, Giuseppe d’Annunzio, Nicola Minuto, Mohamad Maghnie, Mohamad Maghnie   +12 more
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Etiologic distribution and clinical characteristics of pediatric diabetes in 276 children and adolescents with diabetes at a single academic center

BMC Pediatrics, 2021
Background The prevalence of monogenic diabetes is estimated to be 1.1–6.3% of patients with diabetes mellitus (DM) in Europe. The overlapping clinical features of various forms of diabetes make differential diagnosis challenging.
Ja Hye Kim, Yena Lee, Yunha Choi, Gu-Hwan Kim, Han-Wook Yoo, Jin-Ho Choi   +5 more
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Monogenic forms of diabetes

, 2023
Monogenic diabetes is a term used to describe a group of single-gene causes of diabetes. Traditional nomenclature has focused on the types of diabetes known as MODY, defined as maturity-onset diabetes of the young; infantile (or perinatal ...
Salguero, Maria V, Arosemena, Marilyn, et al,, Pollin, Toni   +3 more
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The first presentation of Wolcott‐Rallison syndrome in a four‐month‐old infant with diabetic ketoacidosis (DKA) precipitating by COVID‐19: A case report

Clinical Case Reports, 2021
Monogenic diabetes mellitus (eg, Wolcott‐Rallison syndrome) is a rare condition. It associates with neonatal or early‐infancy insulin‐dependent diabetes.
Elham Maleki, Amir Baniasad, Mina Sepehran, Najmeh Davoudian   +3 more
doaj   +1 more source

Genetics of monogenic diabetes: present clinical challenges [PDF]

, 2018
Purpose of Review Monogenic forms of diabetes have specific treatments that differ from the standard care provided for type 1 and type 2 diabetes, making the appropriate diagnosis essential.
Misra, S, Misra, Shivani, Owen, Katharine R, Owen, Katharine   +3 more
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Monogenic diabetes – an unappreciated problem among physicians

Journal of Medical Science, 2014
Monogenic diabetes results from one or more mutations in a single gene. It is a relatively rare genetic condition, therefore, it was frequently unappreciated among clinicians.
Elżbieta Niechciał, Bogda Skowrońska, Anna Gertig-Kolasa, Izabela Krzyśko, Piotr Fichna   +4 more
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Monogenic diabetes : From genetic insights to population-based precision in care. reflections from a diabetes care editors’ expert forum

, 2020
Individualization of therapy based on a person’s specific type of diabetes is one key element of a “precision medicine” approach to diabetes care. However, applying such an approach remains difficult because of barriers such as disease heterogeneity ...
Pearson, Ewan R., Hattersley, Andrew T., Philipson, Louis H., Carlsson, Annelie, Pearson, Ewan R.; id_orcid, Franks, Paul W., Greeley, Siri Atma W., Rich, Stephen S., Zeitler, Philip S., Nolan, John J., Riddle, Matthew C., Philipson, Louis H.,, Franks, Paul W.,, Carlsson, Annelie,, Zeitler, Philip S.,, Nolan, John J.,, Pearson, Ewan R.,, Riddle, Matthew C.,, Hattersley, Andrew T.,, Rich, Stephen S.,, Greeley, Siri Atma W.,, Lund University.   +21 more
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Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +52 more
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