Results 21 to 30 of about 1,062,540 (244)

The use of precision diagnostics for monogenic diabetes: a systematic review and expert opinion

Communications Medicine, 2023
Background Monogenic diabetes presents opportunities for precision medicine but is underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria and (2) methods for genetic testing for monogenic diabetes, summarized resources
Rinki Murphy, Kevin Colclough, Toni I. Pollin, Jennifer M. Ikle, Pernille Svalastoga, Kristin A. Maloney, Cécile Saint-Martin, Janne Molnes, ADA/EASD PMDI, Shivani Misra, Ingvild Aukrust, Elisa de Franco, Sarah E. Flanagan, Pål R. Njølstad, Liana K. Billings, Katharine R. Owen, Anna L. Gloyn   +16 more
doaj   +1 more source

Diabetes Mellitus Diagnosed in Childhood and Adolescence With Negative Autoimmunity: Results of Genetic Investigation

Frontiers in Endocrinology, 2022
Monogenic diabetes is a rare form of diabetes, accounting for approximately 1% to 6% of pediatric diabetes patients. Some types of monogenic diabetes can be misdiagnosed as type 1 diabetes in children or adolescents because of similar clinical features ...
Marilea Lezzi, Marilea Lezzi, Concetta Aloi, Alessandro Salina, Martina Fragola, Marta Bassi, Marta Bassi, Marina Francesca Strati, Marina Francesca Strati, Giuseppe d’Annunzio, Nicola Minuto, Mohamad Maghnie, Mohamad Maghnie   +12 more
doaj   +1 more source

Etiologic distribution and clinical characteristics of pediatric diabetes in 276 children and adolescents with diabetes at a single academic center

BMC Pediatrics, 2021
Background The prevalence of monogenic diabetes is estimated to be 1.1–6.3% of patients with diabetes mellitus (DM) in Europe. The overlapping clinical features of various forms of diabetes make differential diagnosis challenging.
Ja Hye Kim, Yena Lee, Yunha Choi, Gu-Hwan Kim, Han-Wook Yoo, Jin-Ho Choi   +5 more
doaj   +1 more source

Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes [PDF]

, 2021
This is the author accepted manuscript. The final version is available from the American Diabetes Association via the DOI in this recordData Availability: All the data presented in this manuscript will be made available upon requestType 1 diabetes has a ...
Engler, S, Oram, Richard A., Schatz, Desmond A., Jacobsen, LM, Hattersley, AT, Miller, Douglas R., Mason, Justin R., Hiller, H, Wasserfall, CH, Jacobsen, Laura M., Nick, Harry S., Oram, RA, Engler, Stefanie, Miller, DR, Schatz, DA, Posgai, Amanda L., Kusmarteva, Irina, Hattersley, Andrew T., Kusmarteva, I, Atkinson, MA, Hiller, Helmut, Atkinson, Mark A., Khoshbouei, Habibeh, Lebowitz, JJ, Lebowitz, Joseph J., Wasserfall, Clive H., Posgai, AL, Nick, HS, Beachy, DE, Beachy, Dawn E., Bodenmiller, Bernd, Mason, JR, Khoshbouei, H, Bodenmiller, B   +33 more
core   +2 more sources

Glycemic and Renal Effects of SGLT2 Inhibitors in Monogenic Diabetes: A Real-World National Study. [PDF]

Diabetes Obes Metab
ABSTRACT Aims Evidence regarding the efficacy and safety of sodium–glucose cotransporter 2 inhibitors (SGLT2i) in monogenic diabetes is limited. We evaluated real‐world metabolic, renal, and safety outcomes of SGLT2i therapy in adults with monogenic diabetes.
Audrain E, Bel Lassen P, Bellanné-Chantelot C, Vantyghem MC, Dupuis H, Vidal-Trecan T, Chevalier N, Dubois-Laforgue D, Lamothe S, Vatier C, Villard O, Valéro R, Briet C, Vigouroux C, Ciangura C, Amouyal C.   +15 more
europepmc   +2 more sources

Monogenic diabetes and pregnancy [PDF]

Obstetric Medicine, 2015
Monogenic diabetes is frequently mistakenly diagnosed as either type 1 or type 2 diabetes, yet accounts for approximately 1–2% of diabetes. Identifying monogenic forms of diabetes has practical implications for specific therapy, screening of family members and genetic counselling.
openaire   +2 more sources

Monogenic diabetes : From genetic insights to population-based precision in care. reflections from a diabetes care editors’ expert forum [PDF]

, 2020
Individualization of therapy based on a person’s specific type of diabetes is one key element of a “precision medicine” approach to diabetes care. However, applying such an approach remains difficult because of barriers such as disease heterogeneity ...
Greeley, SAW, Hattersley, AT, Pearson, Ewan R., Hattersley, Andrew T., Carlsson, A, Nolan, JJ, Philipson, Louis H., Carlsson, Annelie, Pearson, Ewan R.; id_orcid, Franks, Paul W., Riddle, MC, Franks, PW, Greeley, Siri Atma W., Pearson, ER, Rich, Stephen S., Philipson, LH, Zeitler, PS, Zeitler, Philip S., Nolan, John J., Rich, SS, Riddle, Matthew C.   +20 more
core   +1 more source

Model for Integration of Monogenic Diabetes Diagnosis Into Routine Care: The Personalized Diabetes Medicine Program

, 2022
OBJECTIVE: To implement, disseminate, and evaluate a sustainable method for identifying, diagnosing, and promoting individualized therapy for monogenic diabetes. RESEARCH DESIGN AND METHODS: Patients were recruited into the implementation study through a
Bromberger, Lee A, Kimball, Amy, Zhang, Haichen, Streeten, Elizabeth A., Carey, David J., Shuldiner, Alan R., Nwaba, Devon, Guan, Yue, Blessing, Kristina, Mathias, Trevor J, Streeten, Elizabeth A, Maloney, Kristin A., Jeng, Linda J.B., Snyder, Mallory N., Sewell, Danielle, Damcott, Coleen M, Mathias, Trevor J., Levin, Philip A, Taylor, Casey O., Ambulos, Nicholas, Maloney, Kristin A, Bromberger, Lee A., Kleinberger, Jeffrey W, Bisordi, Katharine, Levin, Philip, Goehringer, Jessica, Nicholson, Michaela, Pollin, Toni I., Taylor, Casey O, Jeng, Linda B, Damcott, Coleen M., Palmer, Kathleen, Kleinberger, Jeffrey W.   +32 more
core   +1 more source

The first presentation of Wolcott‐Rallison syndrome in a four‐month‐old infant with diabetic ketoacidosis (DKA) precipitating by COVID‐19: A case report

Clinical Case Reports, 2021
Monogenic diabetes mellitus (eg, Wolcott‐Rallison syndrome) is a rare condition. It associates with neonatal or early‐infancy insulin‐dependent diabetes.
Elham Maleki, Amir Baniasad, Mina Sepehran, Najmeh Davoudian   +3 more
doaj   +1 more source

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Lindgren, Cecilia, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +53 more
core   +1 more source