Results 71 to 80 of about 551,561 (307)

Detection of intermediates and kinetic control during assembly of bacteriophage P22 procapsid [PDF]

, 2008
Bacteriophage P22 serves as a model for the assembly and maturation of other icosahedral double-stranded DNA viruses. P22 coat and scaffolding proteins assemble in vitro into an icosahedral procapsid, which then expands during DNA packaging (maturation).
Abendon, Canady, Casjens, Ceres, Earnshaw, Endres, Falkner, Feigin, Fowler, Galisteo, Golub, Guinier, Hendrix, Hiro Tsuruta, Jiang, Kang, Kenneth H. French, Kihara, King, Lanman, Paatero, Paatero, Parent, Parent, Parent, Parker, Parker, Parker, Parker, Parker, Peter E. Prevelige, Prasad, Prevelige, Prevelige, Prevelige, Quinn, Reddy, Roman Tuma, Sakalian, Stockley, Stray, Sun, Svergun, Thuman-Commike, Thuman-Commike, Thuman-Commike, Tuma, Wang, Wang, Wyckoff, Zhang, Zlotnick, Zlotnick, Zlotnick   +53 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

From Structure to Function: Analysis of the First Monomeric Pyridoxal-5′-Phosphate-Dependent Transaminase from the Bacterium Desulfobacula toluolica

Biomolecules
The first monomeric pyridoxal-5′-phosphate (PLP)-dependent transaminase from a marine, aromatic-compound-degrading, sulfate-reducing bacterium Desulfobacula toluolica Tol2, has been studied using structural, kinetic, and spectral methods.
Alina K. Bakunova, Ilya O. Matyuta, Alena Y. Nikolaeva, Tatiana V. Rakitina, Konstantin M. Boyko, Vladimir O. Popov, Ekaterina Yu. Bezsudnova   +6 more
doaj   +1 more source

Influence of auto-organization and fluctuation effects on the kinetics of a monomer-monomer catalytic scheme

, 2000
We study analytically kinetics of an elementary bimolecular reaction scheme of the Langmuir-Hinshelwood type taking place on a d-dimensional catalytic substrate.
A. A. Ovchinnikov, A. Blumen, A. Casties, A. Malevanets, A. Osaki, A. Zangwill, A.A. Ovchinnikov, A.A. Ovchinnikov, C. Flament, D. Avnir, D. ben-Avraham, D. Toussaint, D.C. Torney, D.C. Torney, D.W. Goodman, E. Clément, E. Clément, E. Clément, E. Clément, E.V. Albano, E.V. Albano, F. Collins, G. Oshanin, G. Oshanin, G. Oshanin, G. Oshanin, G. Oshanin, G. Oshanin, G. Oshanin, G. Oshanin, G. Oshanin, G. Oshanin, J. Klafter, K. Fichthorn, K. Fichthorn, K. Lindenberg, L.W. Anacker, M. von Smoluchowski, P. Argyrakis, R. Eiswirth, R. Kopelman, R. Ziff, S. A. Rice, S. F. Burlatsky, S. Redner, S. Redner, S.F. Burlatsky, S.F. Burlatsky, S.F. Burlatsky, S.F. Burlatsky, S.F. Burlatsky, S.F. Burlatsky, S.F. Burlatsky, T.R. Waite, V. Kuzovkov, Y.C. Zhang, Y.E.L. Koo, Ya.B. Zeldovich, Ya.B. Zeldovich   +58 more
core   +1 more source

Role of Rotations on Surface Diffusion of Water Trimers on Pd\{111\} [PDF]

, 2016
Diffusion barriers for a cluster of three water molecules on Pd(111) have been estimated from ab-initio Density Functional Theory. A model for the diffusion of the trimer based in rotations yields a simple explanation of why the cluster can diffuse ...
de Andres, P. L., Ranea, Victor A.
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

PET Glycolysis to BHET Efficiently Catalyzed by Stable and Recyclable Pd-Cu/γ-Al₂O₃

Molecules
Glycolysis of poly(ethylene terephthalate) (PET) is a prospective way for degradation of PET to its monomer bis(hydroxyethyl) terephthalate (BHET), providing the possibility for a permanent loop recycling.
Lei Zhou, Enbo Qin, Hao Huang, Yuanyou Wang, Mingxin Li   +4 more
doaj   +1 more source

Engineering Microbial Chemical Factories to Produce Renewable ‘Biomonomers’

Frontiers in Microbiology, 2012
By applying metabolic engineering tools and strategies to engineer synthetic enzyme pathways, the number and diversity of commodity and specialty chemicals that can be derived directly from renewable feedstocks is rapidly and continually expanding. This
Jake eAdkins, Shawn ePugh, Rebekah eMcKenna, David R. Nielsen   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Conductivity of molecular semiconductor material based on monomeric and polymeric methacroylacetophenone

Semiconductor Physics, Quantum Electronics & Optoelectronics, 2019
The method of impedance spectroscopy was used to study the conductivity of the films of sodium salt of 2-methyl-5-phenylpenten-2-3-5-dione (Namphрd) and polymer based on it that were prepared using drip application from various solvents.
O.S. Berezhnytska
doaj   +1 more source