Protein Target Highlights in CASP16: Insights From the Structure Providers
ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander +34 more
wiley +1 more source
In this study, we analyzed the transcriptome obtained from the pheromone gland isolated from two Israeli populations of the pink bollworm Pectinophora gossypiella to identify viral sequences.
Xiaoyi Dou +4 more
doaj +1 more source
Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N +2 more
wiley +1 more source
Analysis of Paramyxovirus Transcription and Replication by High-Throughput Sequencing. [PDF]
We have developed a high-throughput sequencing (HTS) workflow for investigating paramyxovirus transcription and replication. We show that sequencing of oligo(dT)-selected polyadenylated mRNAs, without considering the orientation of the RNAs from which ...
Davison, AJ +6 more
core +4 more sources
In Silico Identification of Antiviral Peptides as Potential Leads Against Sudan Ebolavirus VP‐40
The continued reemergence of Ebola virus epidemics remains a global health concern, largely due to limited therapeutic interventions. This study is aimed at identifying and characterizing antiviral peptides as potential lead candidates against the Sudan Ebola virus.
Boniface Omara +13 more
wiley +1 more source
Emerging Viral Threats in Rice: A Decade of Discovery and Implications for Crop Protection
ABSTRACT Rice viral diseases pose severe threats to global food security, with over 20 viruses identified in China alone. The advent of high‐throughput sequencing has accelerated the discovery of novel viruses in cultivated and wild rice, unveiling previously undetected threats.
Xinlun Ding +6 more
wiley +1 more source
A comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus [PDF]
The Ebola virus (EBOV) variant Makona (which emerged in 2013) was the causative agent of the largest outbreak of Ebola Virus Disease recorded. Differences in virus-host interactions between viral variants have potential consequences for transmission ...
Aljabr, W +15 more
core +4 more sources
Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley +1 more source
Characterization of the Mycovirome from the Plant-Pathogenic Fungus Cercospora beticola
Cercospora leaf spot (CLS) caused by Cercospora beticola is a devastating foliar disease of sugar beet (Beta vulgaris), resulting in high yield losses worldwide. Mycoviruses are widespread fungi viruses and can be used as a potential biocontrol agent for
Yingxi Li +6 more
doaj +1 more source
Charakterisierung von Oligomerisierungsdomänen des Marburg-Virus Nukleoprotein und deren funktionelle Bedeutung [PDF]
Das phosphorylierte Nukleokapsidprotein NP ist Hauptbestandteil des Marburg-Virus (MARV)-Nukleokapsidkomplexes (NC). Neben NP sind drei weitere virale Strukturproteine, VP35, VP30, L, und die genomische RNA in den NC eingebunden.
Di Carlo, Andrea +1 more
core +1 more source

