Results 111 to 120 of about 148,411 (300)

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Peripheral mononuclear blood cell apheresis in a preclinical ovine model

BMC Veterinary Research, 2018
Background Recent research has demonstrated that circulating peripheral blood mononuclear fractions (PBMC) containing haematopoietic stem (HSC)/progenitor cells have the potential to play a crucial role in regenerative medicine strategies.
Helen Lydon, Roger Brooks, Andrew McCaskie, Frances Henson   +3 more
doaj   +1 more source

Evaluation of the primitive fraction by functional in vitro assays at the RNA and DNA level represents a novel tool for complementing molecular monitoring in chronic myeloid leukemia [PDF]

, 2018
Quantification of BCR-ABL1 mRNA levels in peripheral blood of chronic myeloidleukemia patients is a strong indicator of response to tyrosine-kinase inhibitors (TKI)treatment.
Bianchini, Michele, Cranco, Santiago, Custidiano, María del Rosario, Foncuberta, Cecilia, Freitas, Josefina, Gutierrez, Leandro German, Koile, Daniel Isaac, Larripa, Irene Beatriz, Moiraghi, Beatriz, Mordoh, Jose, Mosqueira, Celeste, Pavlovsky, Carolina, Pérez, Mariel Ana, Ruiz, María Sol, Sanchez, María Belén, Sánchez Ávalos, Julio César Américo, Ventriglia, Verónica, Yankilevich, Patricio   +17 more
core   +1 more source

Characteristics of Human Mononuclear Cell Fractions Separated on the Basis of Theophylline Sensitivity of E Rosette Forming Ability

Immunobiology, 1983
T lymphocytes may be separated into theophylline-sensitive (Tsens) and theophylline-resistant (Tres) fractions based on their loss or retention of ERFC-forming ability after incubation with 3 mM theophylline. It has been claimed that Tsens cells have a predominant suppressor function, whilst Tres cells have mainly helper activity.
S, Divakaran, A G, Wangel
openaire   +2 more sources

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Plasma levels of immunosuppressive mediators during cardiopulmonary bypass

Mediators of Inflammation, 1996
The aim of this study was to evaluate plasma levels of two mediators with immunosuppressive properties, complement fraction C3a (C3a) and transforming growth factor-β1 (TGF-β1), during extracorporeal circulation.
E. Borrelli, P. Giomarelli, A. Naldini, E. Luzzi, S. Silvestri, M. Gardinali, V. Bocci   +6 more
doaj   +1 more source

INFLUENCE OF PREGNA-D’-PENTARANES ON CELL CULTURES HELA AND MONONUCLEAR CELL FRACTION OF PERIPHERAL BLOOD

Russian Journal of Oncology, 2013
The aim of the study. The study of the binding pregna-D’-pentaran with progesterone receptors in the mononuclear cell fraction of peripheral blood (MNFK) and cell culture HeLa, assessment of the compounds impact on cells of these cultures and the level of TNF-alpha in MNFK. Material and methods.
E. N Kareva, I. Solomonovna SLevina, L. E Kulikova, O. S Gorenkova, A. E Manyakhina, N. A Kotsyubinskaya, D. A Tikhonov   +6 more
openaire   +1 more source

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Inhaled Interleukin-10 before and after induction of experimental endotoxemia in the rat : effects on the inflammatory response [PDF]

, 2007
To determine the effects of inhaled IL-10 at different doses and different time points on the pulmonary and systemic inflammatory response during endotoxemia, 48 ventilated, anaesthetized rats (mean body weight ± standard deviation, 500 ± 33g) were ...
Nguyen, Ngoc-Thach
core  

Characterising the transcriptomic response of bovine peripheral blood mononuclear cells to a mycobacterial cell wall fraction

Molecular Immunology
Innate immune stimulants, including mycobacterium cell wall fractions (MCWF), offer an alternative control option to prevent and treat disease in livestock, by appropriately augmenting the innate immune response. However, the functional response to mycobacterium cell wall fractions in cattle is not well defined.
A L, Alexander, E K, Doyle, P, Alexandre, B C, Hine, T, Vuocolo, N M, Andronicos, A, Reverter, I G, Colditz, A B, Ingham   +8 more
openaire   +2 more sources