Results 191 to 200 of about 992,461 (241)

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Single-Cell Transcriptomic Profiling of Peripheral Blood in a Patient with Progressive Thyroid Eye Disease Following Total Thyroidectomy. [PDF]

Genes (Basel)
Mussakulova A, Zhalgasbaeva Z, Korobeynikov V, Zhunussova G.   +3 more
europepmc   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

CarboCell G/C provides sustained high local bone antibiotic levels with minimal systemic exposure, supporting its therapeutic potential in orthopedic infection management. [PDF]

J Bone Jt Infect
Henriksen NL, Jørgensen AR, Poborsky M, Crocoll C, Kotla NG, Berthelsen CJ, Bue M, Jensen LK, Hansen AE, Henriksen JR.   +9 more
europepmc   +1 more source

Functional immune profiling translates T cell dynamics into predictive biomarkers for myeloma immunotherapy. [PDF]

Leukemia
Herzberg F, Lu F, Korenkov M, Fregona V, Didoss C, Heisterkamp N, Sprechert M, Polici A, Heck C, Haas S, Krönke J, Keller U, Bohl SR.   +12 more
europepmc   +1 more source

Catalyst‐Specialized Chemical Language Model Based on Transformer Variational Autoencoder for Catalyst Design and Discovery

Advanced Intelligent Discovery, EarlyView.
We present CatTransVAE, a catalyst‐specialized chemical language model (CLM) built on a transformer variational autoencoder (VAE), developed through pretraining on general compounds followed by fine‐tuning on diverse catalyst databases. A template‐guided generation framework is introduced to enable controlled catalyst design under structural ...
Apakorn Kengkanna, Masahito Ohue
wiley   +1 more source

ScQCenrich enables multi-metric quality control for single-cell RNA sequencing. [PDF]

Commun Biol
Liu Y, Yang C, Wang C, Zhang M, Luo K, Wu L, Xie X.   +6 more
europepmc   +1 more source

ViTAMIn‐O: Democratizing Computer Vision‐Based Machine Learning for Stem Cell Research

Advanced Intelligent Systems, EarlyView.
This study introduces a fully open generalist computer vision model for predicting the differentiation outcomes of stem cell‐based model systems, together with its code‐free deployment platform, ColabViTAMIn‐O. It is benchmarked against various architectures, datasets, and training protocols.
Ferhat Hamurcu, Markus Breunig, Arpad Varga, Bianka Bosch, Jessica Lindenmayer, Anjan T. Kanakappady, Kevin Achberger, Natalia Pashkovskaia, Alexander Kleger, Stefan Liebau, Stefanie Klingenstein, Moritz Klingenstein   +11 more
wiley   +1 more source

Novel glutaminase-free l-asparaginase from <i>Leuconostoc mesenteroides</i> BN1: biochemical properties, molecular dynamics, and anticancer activity. [PDF]

RSC Adv
Charoenwongpaiboon T, Wangpaiboon K, Srichompoo Y, Septham P, Klaihmon P, Khampang S, Issaragrisil S, Lorthongpanich C.   +7 more
europepmc   +1 more source