Results 71 to 80 of about 992,461 (241)

Screening and fractionation of plant extracts with antiproliferative activity on human peripheral blood mononuclear cells

Memorias do Instituto Oswaldo Cruz, 2002
Three hundred and thirteen extracts from 136 Brazilian plant species belonging to 36 families were tested for their suppressive activity on phytohemaglutinin (PHA) stimulated proliferation of human peripheral blood mononuclear cells (PBMC).
Elaine M Souza-Fagundes, Ana BR Queiroz, Olindo Assis Martins Filho, Giovanni Gazzinelli, Rodrigo Corrêa-Oliveira, Tânia MA Alves, Carlos L Zani   +6 more
doaj   +1 more source

Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats

Journal of Functional Biomaterials
This study assessed the impact of implanting mononuclear stem cells and Wharton’s Jelly (WJ), either separately or together, on left ventricular dysfunction following myocardial infarction in Wistar rats.
Luize Kremer Gamba, Laiza Kremer Gamba, Camila da Costa, Aline Luri Takejima, Rossana Baggio Simeoni, Isabella Cristina Mendes Rossa, Anna Clara Faidiga Silva, Julia Letícia de Bortolo, Marcos Antônio Denk, Seigo Nagashima, Carlos de Almeida Barbosa, Paulo Cesar Lock Silveira, Júlio César Francisco, Luiz César Guarita-Souza   +13 more
doaj   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Additive genotoxic effects in cord blood cells upon indirect exposure to chemotherapeutic compounds crossing an in vitro placental barrier

Scientific Reports
Prenatal exposure to toxins can adversely affect long-term health outcomes of the offspring. Though chemotherapeutics are now standard of care for treating cancer patients during pregnancy, certain compounds are known to cross the placenta and harm ...
Carolina Velazquez, Lien Loier, Ilana Struys, Eline Verscheure, Leentje Persoons, Lode Godderis, Liesbeth Lenaerts, Frédéric Amant   +7 more
doaj   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Antibodies directed to antigens secreted by murine epithelioid macrophages modulate BCG-induced granulomata

Mediators of Inflammation, 1993
The authors have previously shown that epithelioid cells isolated from mice secrete a factor, called macrophage deactivating factor (MDF), that promptly deactivates superoxide release by activated macrophages and neutrophils.
Mario Mariano, Tania Aguiar, Celia R. W. Carneiro, Edilberto Postol, Venânclo A. F. Alves, Ricardo Ribeiro-dos-Santos   +5 more
doaj   +1 more source

Resultados iniciais do transplante de células de medula óssea para o miocárdio de pacientes com insuficiência cardíaca de etiologia chagásica Early results of bone marrow cell transplantation to the myocardium of patients with heart failure due to chagas disease

Arquivos Brasileiros de Cardiologia, 2006
OBJETIVO: Avaliar efeitos precoces do transplante de células de medula óssea para o miocárdio de pacientes com insuficiência cardíaca (IC) de etiologia chagásica.
Fábio Vilas-Boas, Gilson S. Feitos, Milena B.P. Soares, Augusto Mota, Joel Alves Pinho-Filho, Augusto José Gonçalves Almeida, Marcus Vinicius Andrade, Heitor G. Carvalho, Adriano Dourado-Oliveira, Ricardo Ribeiro-dos-Santos   +9 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Human Immunodeficiency Virus-Infected Individuals Contain Provirus in Small Numbers of Peripheral Mononuclear Cells and at Low Copy Numbers [PDF]

, 1990
In human immunodeficiency virus (HIV)-infected individuals, the proportion of circulating mononuclear cells (PBMCs) which carry HIV provirus and the number of HIV proviral sequences per infected PBMC have been matters for conjecture.
LUDLAM, CA, Leigh Brown, AJ, BISHOP, JO, SIMMONDS, P, BALFE, P, PEUTHERER, JF   +5 more
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